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Prevention of liver cirrhosis by Silymarin

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dc.contributor.author Zaidi, Syeda Nuzhat Fatima
dc.contributor.author Tabassum Mahboob
dc.date.accessioned 2023-01-10T07:45:49Z
dc.date.available 2023-01-10T07:45:49Z
dc.date.issued 2017-07-20
dc.identifier.citation Fatima Zaidi, S. N., & Mahboob, T. (2017). Prevention of liver cirrhosis by Silymarin. Pakistan journal of pharmaceutical sciences, 30(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15936
dc.description.abstract This study was designed to evaluate the effects of sylimarin supplementation on different biochemical parameters in thioacetamide induced cirrhotic rats. For this purpose 24 male Albino wistar rats were divided into four groups (n=6). Group I, remained healthy control rats, Group II, received thioacetamide (at a dose of 200mg/kg b.w, i.p, for 12 weeks, twice a week) in first phase and saline in second phase, Group III, received thioacetamide (200mg/kg b.w, i.p for 12 weeks, twice a week) in first phase and silymarin (orally at a dosage of 200mg/kg b.w, twice a week, for 8 weeks) in second phase and Group IV, received silymarin (orally at a dosage of 200mg/kg b.w, twice a week, for 8 weeks) in first phase and saline in second phase. Biochemical analysis was evaluated by total and direct bilirubin (Retiman and Franhel, 1957, Sherlock, 1951), liver specific enzymes, antioxidant enzymes [SOD (Kono et al., 1978), Catalase (Sinha et al., 1979), Glutathione reductase (Calberg and Mannervik, 1985) and MDA (Okhawa et al., 1979)] and plasma and intraerythrocyte sodium and potassium (Tabssum et al., 1996). Marked increase in total and direct bilirubin and ALT activity was the indicative markers of liver cirrhosis while reduced antioxidant activity (SOD and GSH) and increased MDA and Catalase levels and disturbed electrolyte homeostasis were observed in cirrhotic group. Silymarin supplementation markedly reduced total bilirubin and ALT activity and restored the antioxidant enzymes (SOD and GSH), MDA and catalase activity and electrolyte homeostasis. These results indicate that silymarin successively attenuates the thioacetamide induced liver cirrhosis. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Botanical Society, University of Karachi en_US
dc.subject Liver cirrhosis en_US
dc.subject Silymarin en_US
dc.subject Thioacetamide en_US
dc.subject Liver enzymes en_US
dc.subject SOD, GSH en_US
dc.subject Catalase, MDA en_US
dc.subject Plasma sodium and potassium en_US
dc.subject Intraerythrocyte sodium en_US
dc.subject potassium en_US
dc.title Prevention of liver cirrhosis by Silymarin en_US
dc.type Article en_US


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