dc.contributor.author |
Zhang, Li |
|
dc.contributor.author |
Liu, Na |
|
dc.contributor.author |
Zhang, Jinying |
|
dc.contributor.author |
Zhang, Hui |
|
dc.contributor.author |
Zhang, Ying |
|
dc.date.accessioned |
2023-01-10T07:52:53Z |
|
dc.date.available |
2023-01-10T07:52:53Z |
|
dc.date.issued |
2017-07-08 |
|
dc.identifier.citation |
Zhang, L., Liu, N., Zhang, J., Zhang, H., & Zhang, Y. (2017). Clinical research of homocysteine, high-sensitive C-reactive protein and D-Dimer in patients with vascular dementia. Pakistan Journal of Pharmaceutical Sciences, 30. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/15950 |
|
dc.description.abstract |
Aim of the present research work was to study the relationship between the degree of dementia and the serum
levels of homocysteine(Hcy), high-sensitive C-reactive protein(hs-CRP), D-Dimer and vascular dementia(VaD) of patients, and to investigate the mechanism of Hcy, hs-CRP and D-Dimer in the vascular dementia. Subjects were divided into normal group and VaD group. CRP and D-Dimer protein of each sample were detected by nephelometry method, and the serum Hcy level was detected by Fluorescent labeling immunoassay method. Compared with the normal control group, Hcy, hs-CRP and D-Dimer in VaD group were significantly higher than that of control group, and the difference was statistically significant. Linear correlation analysis showed a negative association between Hs-CRP, Hcy and MMSE score. There was no correlation between the levels of D-Dimer and the MMSE score. Hcy, hs-CRP and D-Dimer are involved in the pathogenesis of vascular dementia (VAD), There is a significant correlation between the severity of vascular dementia and Hcy and Hs-CRP. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi |
en_US |
dc.subject |
Vascular dementia |
en_US |
dc.subject |
homocysteine |
en_US |
dc.subject |
D-Dimer |
en_US |
dc.subject |
high-sensitive C-reactive protein (hs-CRP) |
en_US |
dc.title |
Clinical research of homocysteine, high-sensitive C-reactive protein and D-Dimer in patients with vascular dementia |
en_US |
dc.type |
Article |
en_US |