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Clinical research of homocysteine, high-sensitive C-reactive protein and D-Dimer in patients with vascular dementia

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dc.contributor.author Zhang, Li
dc.contributor.author Liu, Na
dc.contributor.author Zhang, Jinying
dc.contributor.author Zhang, Hui
dc.contributor.author Zhang, Ying
dc.date.accessioned 2023-01-10T07:52:53Z
dc.date.available 2023-01-10T07:52:53Z
dc.date.issued 2017-07-08
dc.identifier.citation Zhang, L., Liu, N., Zhang, J., Zhang, H., & Zhang, Y. (2017). Clinical research of homocysteine, high-sensitive C-reactive protein and D-Dimer in patients with vascular dementia. Pakistan Journal of Pharmaceutical Sciences, 30. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15950
dc.description.abstract Aim of the present research work was to study the relationship between the degree of dementia and the serum levels of homocysteine(Hcy), high-sensitive C-reactive protein(hs-CRP), D-Dimer and vascular dementia(VaD) of patients, and to investigate the mechanism of Hcy, hs-CRP and D-Dimer in the vascular dementia. Subjects were divided into normal group and VaD group. CRP and D-Dimer protein of each sample were detected by nephelometry method, and the serum Hcy level was detected by Fluorescent labeling immunoassay method. Compared with the normal control group, Hcy, hs-CRP and D-Dimer in VaD group were significantly higher than that of control group, and the difference was statistically significant. Linear correlation analysis showed a negative association between Hs-CRP, Hcy and MMSE score. There was no correlation between the levels of D-Dimer and the MMSE score. Hcy, hs-CRP and D-Dimer are involved in the pathogenesis of vascular dementia (VAD), There is a significant correlation between the severity of vascular dementia and Hcy and Hs-CRP. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Vascular dementia en_US
dc.subject homocysteine en_US
dc.subject D-Dimer en_US
dc.subject high-sensitive C-reactive protein (hs-CRP) en_US
dc.title Clinical research of homocysteine, high-sensitive C-reactive protein and D-Dimer in patients with vascular dementia en_US
dc.type Article en_US


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