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Expression and significance of DDX43 in lung adenocarcinoma

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dc.contributor.author Ma, Ning
dc.contributor.author Xu, Hua-en
dc.contributor.author Luo, Zhifen
dc.contributor.author Zhou, Jianwei
dc.contributor.author Zhou, Yun
dc.contributor.author Liu, Mingyue
dc.date.accessioned 2023-01-10T08:02:04Z
dc.date.available 2023-01-10T08:02:04Z
dc.date.issued 2017-07-16
dc.identifier.citation Ma, N., Xu, H. E., Luo, Z., Zhou, J., Zhou, Y., & Liu, M. (2017). Expression and significance of DDX43 in lung adenocarcinoma. Pakistan Journal of Pharmaceutical Sciences, 30. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15960
dc.description.abstract This paper aims to determine the expression and clinical significance of DDX43 in lung adenocarcinoma. Expression of DDX43 gene and protein of lung adenocarcinoma tissue and para-carcinoma tissues was observed in 27 cases by RT-PCR and immunohistochemistry. These patients were diagnosed as lung adenocarcinoma in the Huaihe Hospital of Henan University from February 2015 to December 2015. The relative ratio of DDX43 mRNA expression in lung adenocarcinoma and para-carcinoma tissues was 0.87±0.62 versus 0.21±0.77 and the difference between the two groups was statistically significant (P<0.01). The expression of DDX43 in normal lung tissues and lung adenocarcinoma tissues was different. The positive rate of DDX43 expression in lung adenocarcinoma tissues was significantly higher than that in normal lung tissues, and the difference was statistically significant (P<0.05). The analysis of clinical pathological characteristics showed that the increase of protein expression was related to the stage and metastasis of lung adenocarcinoma. DDX43 is highly expressed in lung adenocarcinoma, and the expression level is related to the stage and metastasis of lung adenocarcinoma, suggesting that DDX43 is closely related to the occurrence and development of lung adenocarcinoma, and may be a molecular marker for early diagnosis of lung adenocarcinoma. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject DDX43 en_US
dc.subject lung adenocarcinoma en_US
dc.subject RT-PCR en_US
dc.subject immunohistochemistry en_US
dc.subject biomarker en_US
dc.title Expression and significance of DDX43 in lung adenocarcinoma en_US
dc.type Article en_US


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