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Research on the influence of bilateral oophorectomy on the BMD, body components and sex hormone of women during the perimenopause

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dc.contributor.author Wang, HaiLi
dc.contributor.author Wang, Chuchu
dc.contributor.author Sun, Lei
dc.contributor.author Zhou, Shiyuan
dc.contributor.author Wang, Fengyu
dc.date.accessioned 2023-01-10T08:02:45Z
dc.date.available 2023-01-10T08:02:45Z
dc.date.issued 2017-07-17
dc.identifier.citation Wang, H., Wang, C., Sun, L., Zhou, S., & Wang, F. (2017). Research on the influence of bilateral oophorectomy on the BMD, body components and sex hormone of women during the perimenopause. Pakistan Journal of Pharmaceutical Sciences, 30. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15961
dc.description.abstract To investigate the effect of bilateral oophorectomy on bone mineral density, body composition and sex hormone of peri-menopause women. 33 cases of peri-menopause women patients performed bilateral oophorectomy were chosen from xxx gynaecology and obstetrics department of xxx hospital from January 1st,2014 to Dec31th, 2014. And the 33 cases were taken as ovariectomy group. 35 women who were the naturally postmenopausal after menopause collected in clinic and in the same period with the patients of ovariectomy group were taken in control group. American GE-Lunar-Prodigy dual energy X-ray absorptiometry and chemiluminescence method were employed to detect the bone mineral density, fat content, muscle content and sex hormone of the patients in both groups at the 6th and 12th month after menostasis. There was no statistical significance on the comparative difference of bone mineral density, fat content and muscle content at the 6th and 12th month after menostasis between both groups, P>0.05. At the 6th month after menostasis, the estradiol (E2) level in ovariectomy group was significantly lower than that of control group [(14.79±22.17)U/L vs (32.74±31.02U/L)], P<0.05; at the 12th month after menostasis, it had the statistical significance for the comparative difference between the level of E2 and and follicle-stimulating hormone (FSH) in ovariectomy group and that in control group, E2: (8.09±4.38)U/L vs (25.92±3.53)U/L; FSH: (64.88±18.39)U/L vs (40.69±31.63)U/L], P<0.05. the change of E2 and FSH were the main symptom of peri-menopausal women within 12 months after bilateral oophorectomy, the decrease of E2 level had no effect on bone mineral density, fat content and muscle content. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Bilateral oophorectomy en_US
dc.subject peri-menopause en_US
dc.subject estrogen en_US
dc.subject body content en_US
dc.title Research on the influence of bilateral oophorectomy on the BMD, body components and sex hormone of women during the perimenopause en_US
dc.type Article en_US


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