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Antidiabetic and antioxidant effects of tannic acid and melatonin on streptozotocin induced diabetes in rats

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dc.contributor.author Esmaiel, man Mohamad
dc.contributor.author M Abo-youssef, Amira
dc.contributor.author Tohamy, Mohamed AbdAllah
dc.date.accessioned 2023-01-11T03:29:12Z
dc.date.available 2023-01-11T03:29:12Z
dc.date.issued 2019-07-01
dc.identifier.citation Esmaiel, E. M., Abo-Youssef, A. M., & Tohamy, M. A. (2019). Antidiabetic and antioxidant effects of tannic acid and melatonin on streptozotocin induced diabetes in rats. Pakistan Journal of Pharmaceutical Sciences, 32(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15990
dc.description.abstract The present investigation aimed to study the possible antidiabetic and related antioxidant potentials of tannic acid and melatonin in streptozotocin (STZ) induced diabetes in rats. Four groups of rats received intraperitoneal one dose of 50mg/kg body weight STZ for the induction of diabetes. The first group served as diabetic control group and received the vehicle. Four days after induction of diabetes, the remaining three groups received glibenclamide (6mg/kg/day), tannic acid (1 g/kg/day) and melatonin (10 mg/kg/day) for two weeks. A fifth group served as vehicle control group. At the end of the experimental period, blood samples and liver samples were collected for the determination of diabetes correlated biomarkers. Treatment of diabetic rats with tannic acid or melatonin attenuated most of the changes associated with STZ induced diabetes. The present results evidenced the beneficial effects of tannic acid and melatonin in diabetes management. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Diabetes mellitus en_US
dc.subject tannic acid en_US
dc.subject melatonin en_US
dc.subject rat en_US
dc.title Antidiabetic and antioxidant effects of tannic acid and melatonin on streptozotocin induced diabetes in rats en_US
dc.type Article en_US


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