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Effects of Shen-Fu injection on mitochondrial function in the intestinal epithelial cells of rats with endotoxemia

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dc.contributor.author Pan, Cuigai
dc.contributor.author Li, Jiaqiong
dc.contributor.author Han, Guanjie
dc.contributor.author Xu, Tie
dc.contributor.author Li, Maoqin
dc.date.accessioned 2023-01-11T03:29:55Z
dc.date.available 2023-01-11T03:29:55Z
dc.date.issued 2019-07-03
dc.identifier.citation Pan, C., Li, J., Han, G., Xu, T., & Li, M. (2019). Effects of Shen-Fu injection on mitochondrial function in the intestinal epithelial cells of rats with endotoxemia. Pakistan Journal of Pharmaceutical Sciences, 32(4), 1467-1476. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15992
dc.description.abstract Recently, several studies have demonstrated that reactive oxygen species are responsible for inducing multiple organ failure and septic shock. Particularly, mitochondrial dysfunction has been demonstrated in the pathogenesis of multiple organ dysfunction syndrome (MODS). In cytopathic hypoxia, impairment of mitochondrial oxidative phosphorylation decreases aerobic adenosine triphosphate (ATP) production and potentially induces MODS. Shen-Fu (SF) injections are widely used in the treatment of various diseases. SF exhibits cardiovascular protective effects. For example, it can stretch the coronary artery, stabilize blood pressure, regulate IRI, and improve the overall heart function. Clinical studies have demonstrated that SF injections have notable therapeutic effects on septic and hemorrhagic shocks. In the present study, the effects of SF injection on mitochondrial function in the intestinal epithelial cells of rats with endotoxemia were analyzed. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Shen-Fu injection en_US
dc.subject Mitochondrial en_US
dc.subject Intestinal en_US
dc.subject Endotoxemia en_US
dc.title Effects of Shen-Fu injection on mitochondrial function in the intestinal epithelial cells of rats with endotoxemia en_US
dc.type Article en_US


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