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Biological screening of three selected folklore medicinal plants from Pakistan

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dc.contributor.author Zehra Kazmi
dc.contributor.author Naila Safdar
dc.contributor.author Azra Yasmin
dc.date.accessioned 2023-01-11T03:30:17Z
dc.date.available 2023-01-11T03:30:17Z
dc.date.issued 2019-07-04
dc.identifier.citation Kazmi, Z., Safdar, N., & Yasmin, A. (2019). Biological screening of three selected folklore medicinal plants from Pakistan. Pakistan Journal of Pharmaceutical Sciences, 32(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15993
dc.description.abstract This study investigates the pharmacological potential of Adiantum incisum, Alternanthera pungens and Trichodesma indicum. Biological activities of plant extracts (aqueous, methanolic and n-hexane extracts of whole plants) were screened by antitumor potato disc assay (10000, 1000, 100, 10 ppm doses), antifungal tube dilution assay (50, 25, 12.5, 6.25mg/ml) and antioxidant DPPH/reducing power assays (250, 200, 150, 100, 50µg/ml). Significant amount of alkaloids (230.83±30.20mg/g) in Adiantum incisum with lowest amount of phenolics in Alternanthera pungens (43.45 ±14.22µg/mg) were detected. Significant antitumor potential (p<0.05) was revealed by Trichodesma indicum n-hexane extract (85% tumor inhibition; IC50 <10ppm). Moderate to significant antifungal activity (50.73%-78.3%) was shown against Aspergillus niger by Adiantum incisum extracts. Hexane extract of Trichodesma indicum revealed significant antifungal activity (98.9% inhibition) against Mucor specie. Methanolic extracts of all plants displayed significant DPPH radical scavenging potential (96.72%-60.33%; IC50 <50µg/ml) and Ferric power reducing ability with absorbance values (0.164-0.942) very close to standard ascorbic acid. Present study supports the extensive use of these plants in folk medicine and also promotes elaborative in-vivo investigations, isolation of pure therapeutic compounds and formulation of plant-based drugs. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Adiantum incisum en_US
dc.subject Alternanthera pungens en_US
dc.subject antitumor potential en_US
dc.subject phytochemistry en_US
dc.title Biological screening of three selected folklore medicinal plants from Pakistan en_US
dc.type Article en_US


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