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Anti-Inflammatory and antiviral effects of water-soluble crude extract from Phragmites australis in vitro

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dc.contributor.author Liqian Zhu
dc.contributor.author Dong Zhang
dc.contributor.author Chen Yuan
dc.contributor.author Xiuyan Ding
dc.contributor.author Yu Shang
dc.contributor.author Yuting Jiang
dc.contributor.author Guoqiang Zhu
dc.date.accessioned 2023-01-11T03:30:43Z
dc.date.available 2023-01-11T03:30:43Z
dc.date.issued 2017-07-20
dc.identifier.citation Zhu, L., Zhang, D., Yuan, C., Ding, X., Shang, Y., Jiang, Y., & Zhu, G. (2017). Anti-Inflammatory and antiviral effects of water-soluble crude extract from Phragmites australis in vitro. Pakistan journal of pharmaceutical sciences, 30(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15994
dc.description.abstract Phragmitesaustralis (P. australis), a world wide distributed wetland grass, is traditionally used as foodmaking helper and spice in China. The pharmacological effect of this plant is poorly understood. Here, we demonstrated that lipopolysaccharide (LPS)-induced production of inflammatory mediators nitric oxide (NO) and reactive oxygen species (ROS), and the pro-inflammatory cytokines tumor necrosis factor-a (TNF-a) and interleukin-1β (IL-1β) in RAW264.7 macrophage were significantly inhibited by the crude extract. The inflammation pertinent signaling extra cellular signal-regulated kinase 1/2 (Erk1/2), P38MAPK, C-Jun and NF-kappaB (NF-κB) activated by LPS could be dramatically inhibited by this extract. It also remarkably inhibited bovine herpes virus type 1 (BoHV-1) replication in MDBK cells. Taken together, here, for the first time we provided P. australisa a novel natural herb as a potential candidate for the generation of antiviral and anti-inflammatory agent. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Botanical Society, University of Karachi en_US
dc.subject P. australis en_US
dc.subject ROS, NO en_US
dc.subject inflammation en_US
dc.subject BoHV-1. en_US
dc.title Anti-Inflammatory and antiviral effects of water-soluble crude extract from Phragmites australis in vitro en_US
dc.type Article en_US


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