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Intracytoplasmic sperm injection and advanced maternal age: Success or treatment failure?

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dc.contributor.author Rehana Rehman
dc.contributor.author Hafsa Mahmood
dc.contributor.author Fatima Syed
dc.contributor.author Hareem Syed
dc.contributor.author Hina Gul
dc.date.accessioned 2023-01-11T03:32:05Z
dc.date.available 2023-01-11T03:32:05Z
dc.date.issued 2019-07-06
dc.identifier.citation Rehman, R., Mahmood, H., Syed, F., Syed, H., & Gul, H. (2019). Intracytoplasmic sperm injection and advanced maternal age: Success or treatment failure. Pakistan journal of pharmaceutical sciences, 32(4), 1495. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15997
dc.description.abstract Infertility rate documented in Pakistan is 21.9% with only 25% success rate even after procedures like intracytoplasmic sperm injection (ICSI). This rate is further on the decline with enhancement of female age. We aimed to observe the effect of female age on oocyte parameters and reproductive outcome after ICSI. It was done by retrospective analysis of a quasi- experimental design carried out after approval from “Ethical review board of Islamabad clinic serving infertile couples” from July 2010 to August 2011. The response to ovarian stimulation in (282) females was assessed on the basis of groups, A, B, C and D with age ranges up to 25years; 25.1 to 30years; 30.1 to 35years and >35years, respectively. The outcome was assessed as non-pregnant, preclinical abortion and clinical pregnancy groups on the basis of beta hCG and cardiac activity by trans-vaginal scan. We observed that maximum number of pregnancies 32 (38%) occurred in C group, and least 10 (10%) in group A. There was a statistical reduction in the number of mature and fertilized oocytes as the age advanced from group C to D (p<0.05).This shows that reduction in maturity and fertilization of oocytes with advancement of age recommends early referral of couples to assisted reproductive clinics. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Female age en_US
dc.subject infertility en_US
dc.subject intracytoplasmic sperm injection en_US
dc.subject ovarian reserve en_US
dc.title Intracytoplasmic sperm injection and advanced maternal age: Success or treatment failure? en_US
dc.type Article en_US


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