dc.contributor.author | Wen, Li | |
dc.contributor.author | Man, Zhao | |
dc.contributor.author | Yu-zhen, Yu | |
dc.contributor.author | Yan-jie, Hu | |
dc.contributor.author | Xiao-hui, Zhang | |
dc.contributor.author | Kai, Sun | |
dc.contributor.author | Ling, Fu | |
dc.contributor.author | Li Na, Ding | |
dc.date.accessioned | 2023-01-11T03:32:47Z | |
dc.date.available | 2023-01-11T03:32:47Z | |
dc.date.issued | 2019-07-07 | |
dc.identifier.citation | Wen, L., Man, Z., Yu-Zhen, Y., Yan-Jie, H., Xiao-Hui, Z., Kai, S., ... & Na, D. L. (2019). Dissolution rate enhancement of new co-crystals of ezetimibe with maleic acid and isonicotinamide. Pakistan Journal of Pharmaceutical Sciences, 32(4). | en_US |
dc.identifier.issn | 1011-601X | |
dc.identifier.uri | http://142.54.178.187:9060/xmlui/handle/123456789/15999 | |
dc.description.abstract | Ezetimibe (EZT) is a selective cholesterol absorption inhibitor with poor aqueous solubility (0.012mg/ml 23 oC) and low oral bioavailability (about 35-65% for a once 10mg dose). The present study illustrates the preparation and characterization of two new co-crystals of ezetimibe using maleic acid and isonicotinamide as the coformers by solid grinding method. The co-crystal structures were characterized by X-ray powder diffraction (PXRD), differential scanning calorimetry (DSC), infrared spectroscopy (IR) techniques. Crystallinity and surface morphological characteristics of these prepared co-crystals were observed by scanning electron microscope (SEM). Dissolution rate tests demonstrated that both of the new co-crystals showed significant improvement in sodium lauryl sulfate -sodium acetate buffer solution (PH=4.5) at 15min and 20min. This study enriched the types of EZT co-crystals and identified that pharmaceutical co-crystal engineering technique play an important role in the dissolution rate enhancement of ezetimibe. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi | en_US |
dc.subject | Ezetimibe | en_US |
dc.subject | maleic acid | en_US |
dc.subject | isonicotinamide co-crystal | en_US |
dc.subject | solubility | en_US |
dc.subject | dissolution | en_US |
dc.title | Dissolution rate enhancement of new co-crystals of ezetimibe with maleic acid and isonicotinamide | en_US |
dc.type | Article | en_US |