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Dissolution rate enhancement of new co-crystals of ezetimibe with maleic acid and isonicotinamide

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dc.contributor.author Wen, Li
dc.contributor.author Man, Zhao
dc.contributor.author Yu-zhen, Yu
dc.contributor.author Yan-jie, Hu
dc.contributor.author Xiao-hui, Zhang
dc.contributor.author Kai, Sun
dc.contributor.author Ling, Fu
dc.contributor.author Li Na, Ding
dc.date.accessioned 2023-01-11T03:32:47Z
dc.date.available 2023-01-11T03:32:47Z
dc.date.issued 2019-07-07
dc.identifier.citation Wen, L., Man, Z., Yu-Zhen, Y., Yan-Jie, H., Xiao-Hui, Z., Kai, S., ... & Na, D. L. (2019). Dissolution rate enhancement of new co-crystals of ezetimibe with maleic acid and isonicotinamide. Pakistan Journal of Pharmaceutical Sciences, 32(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/15999
dc.description.abstract Ezetimibe (EZT) is a selective cholesterol absorption inhibitor with poor aqueous solubility (0.012mg/ml 23 oC) and low oral bioavailability (about 35-65% for a once 10mg dose). The present study illustrates the preparation and characterization of two new co-crystals of ezetimibe using maleic acid and isonicotinamide as the coformers by solid grinding method. The co-crystal structures were characterized by X-ray powder diffraction (PXRD), differential scanning calorimetry (DSC), infrared spectroscopy (IR) techniques. Crystallinity and surface morphological characteristics of these prepared co-crystals were observed by scanning electron microscope (SEM). Dissolution rate tests demonstrated that both of the new co-crystals showed significant improvement in sodium lauryl sulfate -sodium acetate buffer solution (PH=4.5) at 15min and 20min. This study enriched the types of EZT co-crystals and identified that pharmaceutical co-crystal engineering technique play an important role in the dissolution rate enhancement of ezetimibe. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Ezetimibe en_US
dc.subject maleic acid en_US
dc.subject isonicotinamide co-crystal en_US
dc.subject solubility en_US
dc.subject dissolution en_US
dc.title Dissolution rate enhancement of new co-crystals of ezetimibe with maleic acid and isonicotinamide en_US
dc.type Article en_US


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