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High prevalence of DR-TB (drug-resistant tuberculosis): An Indicator of public health negligence

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dc.contributor.author Rida Masood
dc.contributor.author Iyad Naeem Muhammad
dc.contributor.author Tuba Siddiqui
dc.contributor.author Madiha Mushtaque
dc.contributor.author Asma Irshad
dc.date.accessioned 2023-01-11T04:33:08Z
dc.date.available 2023-01-11T04:33:08Z
dc.date.issued 2019-07-10
dc.identifier.citation Masood, R., Muhammad, I. N., Siddiqui, T., Mushtaque, M., & Irshad, A. (2019). High prevalence of DR-TB (drug-resistant tuberculosis): An Indicator of public health negligence. Pakistan Journal of Pharmaceutical Sciences, 32(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16005
dc.description.abstract Tuberculosis (TB) is among the 10 most common worldwide causes of mortality. In Pakistan, estimated 510,000 tuberculosis patients had been diagnosed with an occurrence of 276/100,000. As per most recent global TB report 2018, Pakistan is amongst the 30 countries high TB with drug-resistant Mycobacterium tuberculosis particularly MDR (multi-drug resistant strains). A retrospective study had been designed using DR-TB patients’ records from January 2013 to the December 2017 year from a public sector hospital in Karachi. Overall 315 drug-resistant tuberculosis patient’s data had been incorporated in the study. All data had been analyzed using SPSS version 16 software. Chi-square test had been used to analyze the data with CI (confidence interval) 95% and level of significance 5%. The study result showed that 64.1% MDR patients, 27.9% MTB rifampicin resistance, 4.8% mono-drug resistant , XDR(1.6%), 1% poly-drug resistant and only 0.6% are MDR suspects showing no association of DR-TB with gender (pvalue 0.787), age group (p-value 0.757), treatment outcomes (p-value 0.549), year of registration( p-value 0.206), first line treatment history(p-value 0.643) with a 95% confidence interval. The drug resistance TB cases have been periodically rising every year. Early identification is required to reduce the percent mortality and inhibit the disease transmission. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject drug-resistant tuberculosis (DR-TB) en_US
dc.subject first-line and second-line antituberculosis treatment. en_US
dc.title High prevalence of DR-TB (drug-resistant tuberculosis): An Indicator of public health negligence en_US
dc.type Article en_US


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