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Optimization of polysaccharide process from Fructus corni with boxbehnken design and antioxidant capacity

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dc.contributor.author Wang, Xinsheng
dc.contributor.author Wu, Yanfang
dc.contributor.author Wang, Fangfang
dc.contributor.author Yi, Junpeng
dc.contributor.author Zhang, Yanping
dc.contributor.author Liu, Pu
dc.contributor.author Niu, Qingshan
dc.date.accessioned 2023-01-13T07:17:00Z
dc.date.available 2023-01-13T07:17:00Z
dc.date.issued 2019-07-11
dc.identifier.citation Wang, X., Wu, Y., Wang, F., Yi, J., Zhang, Y., Liu, P., & Niu, Q. (2019). Optimization of polysaccharide process from Fructus corni with boxbehnken design and antioxidant capacity. Pakistan Journal of Pharmaceutical Sciences, 32(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16026
dc.description.abstract In the present study, the ultrasound-assisted extraction (UAE) process of polysaccharide from Fructus corni (FCP) was opitimized using the Box-Behnken design (BBD). The main parameters including ultrasound time (min), temperature (oC) and solvent to raw material ratio (mL/g) were chosen as the process variables for the optimization of UAE process. The results of analysis of variance indicated that the equation obtained from the experiments could represent the data and the predicted responses satisfactorily. The optimum conditons obtained by BBD were ultrasonic time (51min), temperature (69oC) and solvent to solid ratio (20mL/g) with actual yield (12.68±0.16%), which was good agreement with value predicted by the model. The antioxidant properties of FCP were assessed in vitro based on scavenging effect of the DPPH radical, hydroxyl radical and super oxide radical tests. The FCP possessed strong antioxidant abilities on DPPH and super oxide radical at the high concentration. The results on hydroxyl radical demonstrated that FCP exhibited high scavenging effect when the concentration was over 3000µg/mL. The findings suggested that the FCP had antioxidant capacities and could be developed as a source of natural antioxidants and functional food material. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Fructus corni en_US
dc.subject polysaccharide process en_US
dc.subject box-behnken design en_US
dc.subject antioxidant capacity en_US
dc.title Optimization of polysaccharide process from Fructus corni with boxbehnken design and antioxidant capacity en_US
dc.type Article en_US


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