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Hypoglycemic potential of some seaweeds from Karachi coast of Pakistan

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dc.contributor.author Perveen Akhtar
dc.contributor.author Khan Hira
dc.contributor.author Ambreen
dc.contributor.author Viqar Sultana
dc.contributor.author Jehan Ara
dc.contributor.author Syed EhteshamulHaque
dc.date.accessioned 2023-01-16T09:43:38Z
dc.date.available 2023-01-16T09:43:38Z
dc.date.issued 2019-07-18
dc.identifier.citation Akhtar, P., Hira, K., Sultana, V., Ara, J., & Ehteshamul-Haque, S. (2019). Hypoglycemic potential of some seaweeds from Karachi coast of Pakistan. Pakistan Journal of Pharmaceutical Sciences, 32(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16033
dc.description.abstract Hypoglycemic activity of ethanol extracts and polysaccharides of seaweeds were studied in Sprague Dawley rats. Based on primary screening of ethanol extracts of 10 seaweeds, three Spatoglossum variabile, Stokeyia indica and Sargassum swartzii were selected for further study and polysaccharides were also extracted from them. Ethanol extracts and polysaccharides were administered to alloxan-induced diabetic rats and glucose level, liver and cardiac enzymes were determined. Antidiabetic activity of ethanol extract of three seaweeds S. swartzii, S. indica and S. variabile caused more than 30% reduction in blood glucose after 6 hours atleast on one dose level (2 mg/200 g and/or 10 mg/200 g body weight) in normal and alloxan diabetic rats. Polysaccharides of these three seaweeds also showed anti-diabetic activity after 6 hours atleast on one dose level (1mg/200 g and/ or 2mg/200g body weight) in normal and alloxan diabetic rats. Seaweed extracts and their polysaccharides caused slight alteration in liver and cardiac enzymes like Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT) and Alkaline Phosphatase (ALP). en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Seaweeds en_US
dc.subject ethanol extract en_US
dc.subject polysaccharides en_US
dc.subject hypoglycemia en_US
dc.subject diabetes en_US
dc.subject liver enzymes en_US
dc.title Hypoglycemic potential of some seaweeds from Karachi coast of Pakistan en_US
dc.type Article en_US


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