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In vitro hepatoprotective activity of Sargassum wightii against CCl4 induced hepatic damage

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dc.contributor.author Gunasekaran, Suja
dc.contributor.author Thirumalairaj, Vinoth Kumar
dc.contributor.author Ashokan, Lakshmana Senthil Shanmuga
dc.contributor.author Pitchai, Suganya
dc.contributor.author Yesudas, Rincy
dc.contributor.author Chacko, Amrutha
dc.date.accessioned 2023-01-18T06:13:58Z
dc.date.available 2023-01-18T06:13:58Z
dc.date.issued 2019-07-25
dc.identifier.citation Gunasekaran, S., Thirumalairaj, V. K., Ashokan, L. S. S., Pitchai, S., Yesudas, R., & Chacko, A. (2019). In vitro hepatoprotective activity of Sargassum wightii against [CCI. sub. 4] induced hepatic damage. Pakistan Journal of Pharmaceutical Sciences, 32(4), 1649-1654. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16044
dc.description.abstract In vitro hepatoprotective activity of Sargassum wightii methanolic extract was checked using established cell culture (Hep G2) and primary rat hepatocytes. In Hep G2 cells, the extract concentrations varying from 31.25-500 µg/ml were studied using 1% CCl4 as toxicant. All the extracts showed moderate protectivity against toxicity induced by CCl4 in Hep G2 cells. All the biochemical constraints were determined and compared with that of the control. In this study, an innovator product (silymarin) was used along with the test extracts. In vitro hepatoprotective activity was evaluated by analyzing various parameters such as ALAT, ASAT, ALP, total protein, total bilirubin, TGL and albumin. The results stated that the hepatoprotective potential exhibited by the methanolic extract of Sargassum wightii (SWMH) is active and comparable with the standard. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Hep G2 en_US
dc.subject Hepatocytes en_US
dc.subject Carbon tetrachloride en_US
dc.subject Sargassum wightii en_US
dc.title In vitro hepatoprotective activity of Sargassum wightii against CCl4 induced hepatic damage en_US
dc.type Article en_US


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