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Formulation, characterization and in vitro evaluation of antifungal activity of Nystatin microemulsion for topical application

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dc.contributor.author Iram Maqsood
dc.contributor.author Muhammad Irfan Masood
dc.contributor.author Hafiz Awais Nawaz
dc.contributor.author Iram Shahzadi
dc.contributor.author Naheed Arslan
dc.date.accessioned 2023-01-18T07:08:48Z
dc.date.available 2023-01-18T07:08:48Z
dc.date.issued 2019-07-28
dc.identifier.citation Maqsood, I., Masood, M. I., Nawaz, H. A., Shahzadi, I., & Arslan, N. (2019). Formulation, characterization and in vitro evaluation of antifungal activity of Nystatin microemulsion for topical application. Pakistan journal of pharmaceutical sciences, 32(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16052
dc.description.abstract The current research aims at development and assessment of o/w nystatin microemulsion. The pseudoternary phase diagrams were developed to determine microemulsion existence regions by water titration method. Nystatin was liquefied in the blend of oil phase, surfactant and cosurfactant. Microemulsion was made by deliberate mixing of water and stirring in this blend. The S-mix (surfactant-cosurfactant mixtures) of the ratio 1:2 was found better than 1:1 and 2:1 S-mix ratios. In vitro permeation studies by Franz diffusion cell revealed faster rate of nystatin release from such microemulsion (5.37µg/cm2 /h) as compared to nystrin (4.79µg/cm2 /h), a commercially available aqueous suspension. Kinetic modeling demonstrated zero order drug release and release mechanism found to be anomalous i.e. superposition of dispersion and swelling controlled drug release. Antifungal activity was performed using well diffusion method in vitro against Candida albicans cultures grown on Sabouraud’s dextrose agar. The results also confirmed the high diffusion rate of drug from microemulsion as compared to aqueous suspension. The outcomes of this study propose that topical microemulsion of nystatin provides better antifungal activity as compared to emulsion gels or aqueous suspensions. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Microemulsion en_US
dc.subject nystatin en_US
dc.subject permeation studies en_US
dc.subject flux en_US
dc.subject candida albicans en_US
dc.title Formulation, characterization and in vitro evaluation of antifungal activity of Nystatin microemulsion for topical application en_US
dc.type Article en_US


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