PASTIC Dspace Repository

The prognosis value of C-reactive protein and endothelin-1 in chronic obstructive pulmonary disease patients with pulmonary artery pressure

Show simple item record

dc.contributor.author Yan, Fang
dc.contributor.author Pidayi, Muyeshaer
dc.contributor.author Xia, Yu
dc.contributor.author Hu, Xin
dc.contributor.author Yang, Zengrong
dc.date.accessioned 2023-01-18T07:32:38Z
dc.date.available 2023-01-18T07:32:38Z
dc.date.issued 2019-07-31
dc.identifier.citation Yan, F., Pidayi, M., Xia, Y., Hu, X., & Yang, Z. (2019). The prognosis value of C-reactive protein and endothelin-1 in chronic obstructive pulmonary disease patients with pulmonary artery pressure. Pakistan Journal of Pharmaceutical Sciences, 32(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16055
dc.description.abstract Chronic Obstructive Pulmonary Disease (COPD), which is caused by various proinflammatory cytokines, will present some kinds of complication with progression such as Pulmonary Artery Hypertension (PAH). CRP (C-Reactive Protein) and ET-1(Endotheline-1) play pivotal function in inflammatory responses. The aim of this study is to investigate the prognosis value of CRP and ET-1 in COPD patients with pulmonary artery hypertension. CRP and ET-1 were measured in the plasma, sputum and exhaled breath condensate (EBC) of 55 COPD patients, 75 COPD patients with PAH and 57 healthy controls. Then, we analyzed the influence of these two proteins on the lung function, pulmonary artery pressure, exercise capacity and other clinical indices. The amount of CRP and ET-1 were the highest in COPD patients with PAH, followed by the COPD patients and the healthy controls. And there were statistically significant differences (p<0.05). The amount of CRP and ET-1 were negatively correlated with the lung function and exercise capacity, positively correlated with the pulmonary artery pressure. CRP and ET-1 are two valuable indicators in the diagnosis of COPD patients with PAH in clinic. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Chronic obstructive pulmonary disease en_US
dc.subject proinflammatory cytokines en_US
dc.subject c-reactive protein en_US
dc.subject endotheline-1 en_US
dc.subject pulmonary artery hypertension en_US
dc.title The prognosis value of C-reactive protein and endothelin-1 in chronic obstructive pulmonary disease patients with pulmonary artery pressure en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account