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REVIEW Novel synthetic curcuminoids: Not merely an anticancer agent

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dc.contributor.author Zhang, Hailei
dc.contributor.author Jiang, Xiaonan
dc.contributor.author Song, Weihua
dc.contributor.author Yang, Zhangqun
dc.date.accessioned 2023-01-19T04:05:32Z
dc.date.available 2023-01-19T04:05:32Z
dc.date.issued 2019-08-05
dc.identifier.citation Zhang, H., Jiang, X., Song, W., & Yang, Z. (2019). Novel synthetic curcuminoids: Not merely an anticancer agent. Pakistan Journal of Pharmaceutical Sciences, 32(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16061
dc.description.abstract Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to exhibit biological activity towards different kinds of diseases. But the low oral bioavailability results in a limited application in clinic treatment. Recently, numerous curcumin derivatives were synthesized by the modification of three important functional groups: The aromatic o-methoxy phenolic group, a seven conjugated carbon linker and the β-diket one moiety. However, many people know curcumin only as an anticancer agent and overlook the diverse biological activities of curcumin and curcumin-based derivatives. In this article, we summarized the novel synthetic curcuminoids by different therapeutic activities including antioxidant activity, anti-HIV activity, stimulating activity of gastric emptying, antiinflammatory activity, ACE inhibition activity, prevention of Parkinson’s disease, anti-parasitism, anti-obesity, prevention of Alzheimer’s disease, and antibacterial activity. The relation between structural features and activities were also investigated. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Curcumin en_US
dc.subject curcuminoid en_US
dc.subject therapeutic activity en_US
dc.subject structure en_US
dc.title REVIEW Novel synthetic curcuminoids: Not merely an anticancer agent en_US
dc.type Article en_US


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