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Ethanolic seeds extract of Centratherum anthelminticum reduces oxidative stress in type 2 diabetes

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dc.contributor.author Hina Akram Mudassir
dc.contributor.author Shamim A Qureshi
dc.contributor.author Muhammad Bilal Azmi
dc.contributor.author Muhammad Ahsan
dc.date.accessioned 2023-01-19T04:24:34Z
dc.date.available 2023-01-19T04:24:34Z
dc.date.issued 2018-05-04
dc.identifier.citation Mudassir, H. A., Qureshi, S. A., Azmi, M. B., & Ahsan, M. (2018). Ethanolic seeds extract of Centratherum anthelminticum reduces oxidative stress in type 2 diabetes. Pak. J. Pharm. Sci, 31(3 Suppl), 991-995. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16065
dc.description.abstract This work was accomplished to assess the in-vitro antiglycation and antioxidant activities of ethanolic seeds extract of Centratherum anthelminticum (CSEt), followed by its in-vivo examination in type 2 diabetes. Overnight fasted rabbits were divided into control and diabetic groups. Rabbits in diabetic group were fed with 35% fructose solution to develop hyperglycemia that was well-monitored by glucometer. These were divided into diabetic control (distilled water 1ml/kg), positive control group (pioglitazone 15mg/kg) and two test groups (CSEt 400 and 600mg treated). All treatments were given orally. After 14 days, rabbits were sacrificed and blood samples were used to estimate glycated haemoglobin (HbA1c) while total bilirubin (direct and indirect), uric acid, alanine aminotransferase (ALT) and creatine kinase (CK) were done in sera. In addition, antioxidant parameters viz., catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH) and lipid peroxidation (LPO) were in liver tissues. The in-vitro studies showed good antiglycation and antioxidant potential of CSEt. Similarly, in-vivo investigation showed significant reduction in glycemia and body weights in type 2 diabetic test groups. Plus values of HbA1c, ALT, CK, uric acid and bilirubin were almost back to normal along with improvement found in efficiency of antioxidant parameters. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Centratherum anthelminticum en_US
dc.subject fructose en_US
dc.subject type 2 diabetes en_US
dc.subject antioxidant parameters en_US
dc.title Ethanolic seeds extract of Centratherum anthelminticum reduces oxidative stress in type 2 diabetes en_US
dc.type Article en_US


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