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Effects of Costus speciosus ethanolic extract on male rats: The action mechanism and the ability to impregnate

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dc.contributor.author Sari, Ika Puspita
dc.contributor.author Nurrochmad, Arief
dc.contributor.author Setiawan, Irfan Muris
dc.contributor.author Hertiani, Triana
dc.contributor.author Paramita, Annisa Dian
dc.contributor.author Annisa, Anggit Yustitia
dc.date.accessioned 2023-01-19T04:25:43Z
dc.date.available 2023-01-19T04:25:43Z
dc.date.issued 2018-05-05
dc.identifier.citation Sari, I. P., Nurrochmad, A., Setiawan, I. M., Hertiani, T., Paramita, A. D., & Annisa, A. Y. (2018). Effects of Costus speciosus ethanolic extract on male rats: The action mechanism and the ability to impregnate. Pakistan Journal of Pharmaceutical Sciences, 31. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16066
dc.description.abstract To examine the action mechanism that mediates the anti-fertility effect of Costus speciosus extract, research was conducted on male Sprague-Dawley rats. Costus extract was given to male rats for 14 days at various doses, namely 275, 550 and 1,100 mg kg-1 day-1 in 0.5% sodium CMC. The results showed that Costus extract with doses ranging from 275 to 1,100 mg kg-1 day-1 was able to inhibit pregnancy among female rats by 10-70%. No obstacles in terms of sexual behavior were identified among male rats. The anti-fertility effect of Costus extract kicked in without involving a decreased level of male reproductive hormones. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Costus extract en_US
dc.subject reproductive hormones en_US
dc.subject obstacles to pregnancy en_US
dc.subject sexual behavior en_US
dc.title Effects of Costus speciosus ethanolic extract on male rats: The action mechanism and the ability to impregnate en_US
dc.type Article en_US


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