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Microwave and conventional synthesis of Co (II), Cu (II) and Ni (II) metal complexes of some acid hydrazones with their spectral characterization and biological evaluation

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dc.contributor.author Mussarat Jabeen
dc.contributor.author Karamat Mehmood
dc.contributor.author Khan, Misbah-ul Ain
dc.contributor.author Noreen Aslam
dc.contributor.author Ansa Madiha Zafar
dc.contributor.author Naveed Sajid
dc.contributor.author Shazia Noreen
dc.contributor.author Samina Aslam
dc.contributor.author Abdul Ghafoor
dc.date.accessioned 2023-01-19T04:27:11Z
dc.date.available 2023-01-19T04:27:11Z
dc.date.issued 2018-05-06
dc.identifier.citation Jabeen, M., Mehmood, K., Khan, M. U. A., Aslam, N., Zafar, A. M., Sajid, N., ... & Ghafoor, A. (2018). Microwave and conventional synthesis of Co (II), Cu (II) and Ni (II) metal complexes of some acid hydrazones with their spectral characterization and biological evaluation. Pakistan Journal of Pharmaceutical Sciences, 31. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16067
dc.description.abstract The transition metal complexes of Co(II), Ni(II), and Cu(II) derived from N'-((5-(2,5-dichlorophenyl)furan-2- yl)methylene)-2-hydroxybenzohydrazide (L24) and N'-((5-(2, 5-dichlorophenyl)furan-2-yl)methylene)benzohydrazide (L21) have been synthesized by conventional as well as microwave method being shorter time consuming, solvent less and gives improved yields as compared to the traditional conventional technique. These compounds were characterized by melting point, TLC, FTIR, 1 H-NMR, elemental analysis, potentiometric titration, ICP-OES and EIMS. From this analytical data it is confirmed that complexes are in octahedral structure with coordination number 6 which revealed 1:2 (metal:ligand). FTIR data shows that these synthesized hydrazone ligands have ONO donor sites and coordinate with transition metal ions in a tridentate monobasic manner. All these synthesized compounds were tested for evaluation of antibacterial activity by agar disc diffusion assay and total antioxidant activity by Phosphomolybdenum method. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Conventional method en_US
dc.subject microwave method en_US
dc.subject hydrazone en_US
dc.subject antibacterial en_US
dc.subject antioxidants en_US
dc.title Microwave and conventional synthesis of Co (II), Cu (II) and Ni (II) metal complexes of some acid hydrazones with their spectral characterization and biological evaluation en_US
dc.type Article en_US


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