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Inhibition of diet-restriction-induced behavioral deficits by tryptophan administration in rats

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dc.contributor.author Darakhshan M Saleem
dc.contributor.author Shafaque Mehboob
dc.contributor.author Khan, Moona Mehboob
dc.contributor.author Noreen Samad
dc.contributor.author Afshan Zafar
dc.contributor.author Darakhshan J Haleem
dc.date.accessioned 2023-01-19T04:29:03Z
dc.date.available 2023-01-19T04:29:03Z
dc.date.issued 2018-05-08
dc.identifier.citation Saleem, D. M., Mehboob, S., Khan, M. M., Samad, N., Zafar, A., & Haleem, D. J. (2018). Inhibition of diet-restriction-induced behavioral deficits by tryptophan administration in rats. Pakistan Journal of Pharmaceutical Sciences, 31(3), 1021-1030. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16069
dc.description.abstract Diet has a great impact on brain health and function. It plays an important role to improve and control a number of psychiatric disorders such as depression, anxiety, hyperactivity and behavioral impulsivity. Anorexia Nervosa (AN) is one of the psychiatric disorder which is associated with diet. In AN, patients show extreme dieting, weight loss, hyperactivity, depression/anxiety, self-control and behavioral impulsivity. Previous studies showed that during diet restriction, tryptophan decreases serotonin (5-hydroxytryptamine; 5-HT) metabolism in the brain due to its less availability and contributes psychiatric problems associated with AN. The present study is designed to investigate the effects of tryptophan administration on 5-HT metabolism in diet-restricted rats. Tryptophan at a dose of 50 or 100mg/kg was given orally to respective freely fed (FF) or diet restricted (DR) animals daily for five weeks. Behavioral activities were also monitored weekly. The results show significant effect (p<0.05) on behavior in activity box, open field and in light/dark transition test by tryptophan administration in diet-restricted rats. This may be associated with the increased in serum tryptophan and brain 5-HT metabolism. Therefore, it is concluded that diet-restriction-induced behavioral changes might be reverted back with the administration of tryptophan and may be helpful to improve psychological problems in AN. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Tryptophan en_US
dc.subject serotonin en_US
dc.subject hyper activity en_US
dc.subject behavioral deficits en_US
dc.subject diet-restriction en_US
dc.title Inhibition of diet-restriction-induced behavioral deficits by tryptophan administration in rats en_US
dc.type Article en_US


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