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Chemical composition and antioxidant activity of phenolic compounds from Dioscorea (Yam) leaves

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dc.contributor.author Zhou, Li
dc.contributor.author Shi, Xinmin
dc.contributor.author Ren, Xiangmei
dc.contributor.author Qin, Zhihong
dc.date.accessioned 2023-01-19T04:29:45Z
dc.date.available 2023-01-19T04:29:45Z
dc.date.issued 2018-05-09
dc.identifier.citation Zhou, L., Shi, X., Ren, X., & Qin, Z. (2018). Chemical composition and antioxidant activity of phenolic compounds from Dioscorea (Yam) leaves. Pakistan Journal of Pharmaceutical Sciences, 31. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16070
dc.description.abstract This study was aimed to assess the potential of Dioscorea (yam) leaves as a source of antioxidants. Microwave-assisted extraction (MAE) process was used to prepare the extracts. The phenolic compounds in Dioscorea leaves extracts were analyzed by HPLC-DAD-ESI-MS/MS method and the contents of major compounds were determined. Results indicated that a total of 17 phenolic compounds were separated identified by means of UV and mass spectra compared with authentic reference substances and/or reported values in the literature. The main phenolic compound was rosmarinic acid and its highest amount was found in Dioscorea glabra Roxb. leaves (22.31±1.33 mg/g DW). Rutin was the dominant flavonoid followed by quercetin which highest amount was found in Dioscorea alata leaves (8.66±0.29 mg/g DW). Antioxidant activity of the extracts was estimated by the use of DPPH and ABTS assays. Both kinds of leaves exhibited satisfied antioxidant capacity which was correlated with phenolic contents. In the cytoprotective effect on HUVECs viability assay, Dioscorea glabra Roxb. leaves extract was found to be more active than that of Dioscorea alata against H2O2-induced oxidative stress. Our findings support the promising role of Dioscorea leaves that can be used as an interesting source of phenolic antioxidants. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Microwave-assisted extraction en_US
dc.subject Microwave-assisted extraction en_US
dc.subject phenolic compounds en_US
dc.subject antioxidant activity en_US
dc.subject cytoprotective en_US
dc.title Chemical composition and antioxidant activity of phenolic compounds from Dioscorea (Yam) leaves en_US
dc.type Article en_US


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