PASTIC Dspace Repository

Effect of aerobic exercise combined with ginkgo polysaccharide on weight, blood glucose and glycosylated serum protein in diabetic rats

Show simple item record

dc.contributor.author Zhu, Rongkun
dc.contributor.author Xie, Jun
dc.date.accessioned 2023-01-19T04:31:18Z
dc.date.available 2023-01-19T04:31:18Z
dc.date.issued 2018-05-11
dc.identifier.citation Zhu, R., & Xie, J. (2018). Effect of aerobic exercise combined with ginkgo polysaccharide on weight, blood glucose and glycosylated serum protein in diabetic rats. Pakistan Journal of Pharmaceutical Sciences, 31. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16072
dc.description.abstract Streptozotocin copied diabetic rats model were studied through aerobic exercise combined with ginkgo polysaccharide. Aimed to offering the updating experimental basis to prevent diabetic through aerobic exercise combined with ginkgo polysaccharide, the effect of aerobic exercise combined with ginkgo polysaccharide were discussed on the weight, blood glucose, glucosylated serum protein and the secretion ability of islet β cells, oral glucose tolerance test, islet cell pathological morophological changes and positive expression of Bax and Bcl-2. At the end of the experiment, the parameters changes were detected, which were body weight, weight of pancreas islet, Fasting blood glucose(FGB), glycosylated serum protein(GSP), FINS, C-peptide, glucose kinase (GK), ultramicro total atpase, ultramicro Na+ K+ - atpase, altramicro Ca2-M2+-atpase, β cell function index (HBCI), and oral glucose tolerance test (OGTT). HE dyeing technology was applied on insulin for pathological morphology observation. The positive expression changes of islet β cells Bcl-2 and Bax were detected by immunohistochemical staining and semi-quantitative method of stereology. Experimental results proved that body weight, GK, ultra micro Na+ K+ -atpase, ultra micro Ca2+M2+-atpase, C peptide were significantly increased after the intervention of ginkgo polysaccharide (P<0.05), correspondingly, insulin levels were dramatic increased (P<0.01), while blood glucose and GSP were decreased significantly (P<0.05), the ultramicro total atpase decrease, without statistically significance. After the exercise intervention, body weight, ultra micro Na+ K+ - atpase, ultra micro Ca2+M2+-atpase, C peptide significantly increased (P<0.05), insulin level apparently increased (P<0.01), blood glucose and GSP dramatically decreased (P<0.05), GK and ultra micro total atpase had an elevated trend, while without statistically significance. After the rational exercise combined with ginkgo polysaccharide intervention, GK, ultra micro total atpase, ultra micro Na+ K+ -atpase, ultra micro Ca2+M2+-atpase and insulin level significantly increased (P<0.05), body weight and c peptide significantly increased (P<0.01), blood glucose and GSP obviously decreased (P<0.01). The pathological changes of insulin in diabetic rats were improved. The increased ratio of Bcl-2/Bax enabled the pancreatic β cell developed in the direction of repair and regeneration. The combination of aerobic exercise and ginkgo polysaccharide could help to increase insulin secretion in diabetic rats, and increase insulin reserve and secretion capacity. Then it can control the weight boss of diabetic rats, along with the blood glucose. So it could lead to the development of the pancreas islets of diabetic rats in the direction of repair and regeneration. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Exercise en_US
dc.subject PGBL en_US
dc.subject diabetes en_US
dc.subject islet β cells en_US
dc.subject function en_US
dc.title Effect of aerobic exercise combined with ginkgo polysaccharide on weight, blood glucose and glycosylated serum protein in diabetic rats en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account