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Hypoglycemic and hypolipidemic activities of crude seeds of Centratherum anthelminticum in healthy volunteers and type 2 diabetic patients

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dc.contributor.author Hina Akram Mudassir
dc.contributor.author Qureshi, Shamim Akhter
dc.contributor.author Muhammad Bilal Azmi
dc.contributor.author Muhammad Ahsan
dc.contributor.author Musab Kamran
dc.contributor.author Sakina Jafar
dc.date.accessioned 2023-01-19T04:33:23Z
dc.date.available 2023-01-19T04:33:23Z
dc.date.issued 2018-05-13
dc.identifier.citation Mudassir, H. A., Qureshi, S. A., Azmi, M. B., Ahsan, M., Kamran, M., & Jafar, S. (2018). Hypoglycemic and hypolipidemic activities of crude seeds of Centratherum anthelminticum in healthy volunteers and type 2 diabetic patients. Pakistan Journal of Pharmaceutical Sciences, 31(3 (Supplementary)), 1061-1065. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16074
dc.description.abstract This study first time reports the hypoglycaemic activity of crude seeds powder (CSP) of Centratherum anthelminticum in healthy and type 2 diabetic volunteers. In addition, hypolipidemic effect of same CSP was also determined in healthy volunteers. Healthy individuals were divided into control and two test groups T1 and T2 treated with 200 & 400mg of CSP. Similarly, type 2 diabetic patients were also divided into positive control (PC) treated with metformin 600mg and two test groups DT1 (CSP 400mg + metformin 600mg) & DT2 (CSP 400mg). Each group has 6 individuals and each treatment was done orally. CSP 400mg was found more hypoglycaemic on all time intervals from 30 to 120min when oral glucose tolerance test was conducted in healthy volunteers. Both test quantities of CSP 200 & 400 mg were found successful in same healthy personsin decreasing the levels of triglycerides & total cholesterol (p<0.05), low & very low density lipoprotein cholesterols (p<0.01) and keeping the level of high density lipoprotein cholesterol as same as it was observed in control group. Similarly, CSP 400mg along with metformin and alone was also found helpful in lowering the fasting blood glucose levels in type 2 diabetic patients (DT1 & DT2) -24.99% and -20.62% respectively as compared to diabetic group only treated with metformin (PC), (p<0.01). Therefore, CSP of C. antheminticum proves effective hypoglycaemic and hypolipidemic agent by possibly inducing glucose tolerance in healthy individuals and type 2 diabetic patients. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject CSP en_US
dc.subject type 2 diabetes en_US
dc.subject hypoglycaemia en_US
dc.subject C. anthelminticum en_US
dc.title Hypoglycemic and hypolipidemic activities of crude seeds of Centratherum anthelminticum in healthy volunteers and type 2 diabetic patients en_US
dc.type Article en_US


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