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Synthesis, characterization and antihypertensive activity of 2-phenyl substituted benzimidazoles

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dc.contributor.author Khan, Muhammad Tariq
dc.contributor.author Muhammad Tahir Razi
dc.contributor.author Syed Umer Jan
dc.contributor.author Muhammad Mukhtiar
dc.contributor.author Rahman Gul
dc.contributor.author IzharUllah
dc.contributor.author Abid Hussain
dc.contributor.author Asif Mehmood Hashmi
dc.contributor.author Muhammad Taufiq Ahmad
dc.contributor.author Nisar Ahmed Shahwani
dc.contributor.author Imran Rabbani
dc.date.accessioned 2023-01-19T04:34:22Z
dc.date.available 2023-01-19T04:34:22Z
dc.date.issued 2018-05-14
dc.identifier.citation Khan, M. T., Razi, M. T., Jan, S. U., Mukhtiar, M., Gul, R., Hussain, A., & Rabbani, I. (2018). Synthesis, characterization and antihypertensive activity of 2-phenyl substituted benzimidazoles. Pak. J. Pharm. Sci, 31(3), 1067-1074. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16075
dc.description.abstract Hypertension is one of cardiovascular disease that is not sufficiently prevented and controlled at both hospital and community levels. Hypertension resulted in significant morbidity and mortality. The benz-imidazole ring is very important pharmacophore in modern drug discovery. The substituted benzimidazoles are the important for medicinal research. Researchers have reported that substituted Benzimidazoles are the structural isosteres of nucleotides, and easily allow them to interact with the different biopolymers, possess pharmacological activity especially antihypertensive activity. Angiotensin II Receptor Antagonists/Blockers (ARBs) compete with angiotensin II at the receptor site and block the contractile effect of angiotensin II in all vascular smooth muscles. Among all Angiotensin II Receptor Antagonists/Blockers (ARBs), Telmisartan, Milfasartan and many others have benzimidazole ring in their structure. In this study Angiotensin II Receptor Antagonists/Blockers (ARBs) have been prepared. Synthesized compounds were characterized by physical data and FTIR spectroscopic technique. Synthesized compounds studied were finally screened for their antihypertensive activity by tail cuff method of measurement of blood pressure by NIBP apparatus (None Invasive Blood Pressure) using Chart 5.0 software. The compounds synthesized were 2-(3- nitrophenyl)-1Hbenzimidazole (1a), 3-(1H benzimidazol-2-yl)aniline (1b) and 5-(1H-benzimidazol-2-yl)-2- methoxyphenol (1c). The synthesized compounds have shown antihypertensive activity by taking Losartan as lead compound. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Hypertension en_US
dc.subject benzimidazole en_US
dc.subject Telmisartan en_US
dc.subject Milfasartan en_US
dc.subject Losartan en_US
dc.subject 2-phenyl substituted benzimidazoles and Antihypertensive activity en_US
dc.title Synthesis, characterization and antihypertensive activity of 2-phenyl substituted benzimidazoles en_US
dc.type Article en_US


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