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Anticholinergic drug atropine diminishes newly formed fear memory in male rats

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dc.contributor.author Sahar Rafiq
dc.contributor.author Saara Ahmad
dc.contributor.author Fatima Ahmed
dc.contributor.author Zehra Batool
dc.contributor.author Saad Bilal Ahmed
dc.contributor.author Sadia Saleem
dc.contributor.author Fizza Naqvi
dc.contributor.author Laraib Liaquat
dc.contributor.author Asia Afzal
dc.contributor.author Saida Haider
dc.date.accessioned 2023-01-19T04:35:21Z
dc.date.available 2023-01-19T04:35:21Z
dc.date.issued 2018-05-15
dc.identifier.citation Rafiq, S., Ahmad, S., Ahmed, F., Batool, Z., Ahmed, S. B., Saleem, S., ... & Haider, S. (2018). Anticholinergic drug atropine diminishes newly formed fear memory in male rats. Pakistan journal of pharmaceutical sciences, 31. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16076
dc.description.abstract Post-traumatic stress disorder (PTSD) is a condition which is triggered shortly after experiencing traumatic events. PTSD is complicated by the fact that people with PTSD often develop additional disorders such as phobias, addiction, depression, panic disorder and obsessive–compulsive disorder. Beta-adrenergic and cholinergic system both are involved in memory formation as well as in emotional response associated with memory. It is reported that the administration of beta-adrenergic and cholinergic antagonist results in the impairment in memory formation. Here, we examined the potential of beta-adrenergic antagonist propranolol and muscarinic cholinergic antagonist atropine for impairing the recently formed fear memory associated with PTSD. Reconsolidation is the memory process during which labile memory converts into permanent memory. In this study it is hypothesized that if recently formed fear memory is disturbed during reconsolidation phase by pharmacological intervention then it could be possible to impair wellconsolidated fear memory. Atropine and propranolol were injected in separate set of rats (n=6) just after the reactivation of fear memory. Short term memory and long term memory were monitored after 2 h and 24 h of reactivation respectively. Results of current study demonstrated that only atropine showed significant impairment of reconsolidation of newly formed fear memory whereas propranolol did not show fear memory disrupting effects. The results emphasize the significance of pharmacological intervention to impair reconsolidation of newly formed fear memory. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Atropine en_US
dc.subject Pavlovian fear conditioning en_US
dc.subject propranolol en_US
dc.subject reconsolidation en_US
dc.title Anticholinergic drug atropine diminishes newly formed fear memory in male rats en_US
dc.type Article en_US


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