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Epigallocatechin gallate inhibits corneal neovascularization in ratalkaline burn model

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dc.contributor.author Li, Huiyan
dc.contributor.author Ye, Bei
dc.contributor.author Zhu, Lili
dc.contributor.author Wu, Lianqun
dc.date.accessioned 2023-01-19T04:36:49Z
dc.date.available 2023-01-19T04:36:49Z
dc.date.issued 2018-05-17
dc.identifier.citation Huiyan, L., Bei, Y., Lili, Z., & Lianqun, W. (2018). Epigallocatechin gallate inhibits corneal neovascularization in ratalkaline burn model. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16078
dc.description.abstract To evaluate the effectiveness of epigallocatechin gallate (EGCG) in inhibiting corneal neovascularization in rat alkaline burn model. Corneal neovascularization model was induced by sodium hydroxide alkaline burn injury in SD rats. Rats were randomly divided into two groups and were given intraperitoneal injection with EGCG or PBS per day for up to 14 days respectively. Corneal inflammation and neovascularization area were assessed on days3, 7, and 14 after cauterization with digital photographs. Vascular endothelial growth factor (VEGF) and pigment epithelium derived factor (PEDF) mRNA levels were measured by reverse transcription-polymerase chain reaction (qRT-PCR). The nucleartransfactor-Κb (NF-κB) subunit P65 protein was assayed by immunohistochemistry. The differences of corneal inflammation scores between two groups were significant. The area of CNV between two groups had no significant difference on day3 but have significant difference on days 7 and 14.The PDEF mRNA expression in EGCG group was significantly higher and the expression of VEGF mRNA was lower than those in PBS group. The results of immunohistochemistry showed from day 7, expression of NF-κB P65protein was suppressed considerably in EGCG group. This study demonstrates that EGCG inhibits corneal neovascularization in a rat model induced by alkali burn. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject EGCG en_US
dc.subject corneal neovascularization en_US
dc.subject VEGF en_US
dc.subject PEDF en_US
dc.subject NF-κB en_US
dc.title Epigallocatechin gallate inhibits corneal neovascularization in ratalkaline burn model en_US
dc.type Article en_US


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