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Counter irritant activity of Carthamus oxycantha

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dc.contributor.author Syed Saeed ul Hassan
dc.contributor.author Imran Waheed
dc.contributor.author Muhammad Khalil-ur-Rehman
dc.contributor.author Uzma Niaz
dc.contributor.author Muhammad Asif Saeed
dc.date.accessioned 2023-01-19T04:38:17Z
dc.date.available 2023-01-19T04:38:17Z
dc.date.issued 2013-07-02
dc.identifier.citation ul Hassan, S. S., Waheed, I., Khalil-ur-Rehman, M., Niaz, U., & Saeed, M. A. (2013). Counter irritant activity of Carthamus oxycantha. Pak. J. Pharm. Sci, 26(4), 665-672. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16080
dc.description.abstract Many locally occurring species of Asteraceae are used as medicinal plants by various tribal and ethnic communities in Pakistan. Carthamus oxycantha is often occurs as weed in cultivated fields. Folk medicines indicated its use as an anti inflammatory and wound healing plant. It is used for wound healing by the local population in the form of powder paste. No scientific report, about the behavior of this plant has so far been published. The counter irritant studies of locally occurring Carthamus oxycantha was carried out. The main objectives of the project were to evaluate its wound healing effects on animal skin and the identity and characterization of chromatographically isolated fractions. For this purpose, different solvents with a broad range of polarity were successively used to extract non-polar compounds (petroleum ether extract), constituents intermediate polarities (chloroform extract) and polar constituents (methanol extract) from the whole herb of Carthamus oxycantha. The counter irritant activity of the crude extracts and isolated fractions was evaluated on rabbit’s skin. Five fractions Co-1 to Co-5 were isolated from the active chloroform extract by column and thin layer chromatography. Co-1, Co-3 and Co-5 appeared to be the most potent counter irritant than others. A possible structure-activity relationship of these active compounds was investigated by using spectroscopy (UV and FTIR analysis). en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Oxycantha en_US
dc.subject Counter irritant en_US
dc.subject chromatography en_US
dc.subject rabbit’s skin en_US
dc.subject spectroscopy en_US
dc.title Counter irritant activity of Carthamus oxycantha en_US
dc.type Article en_US


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