dc.contributor.author |
Asma Noureen |
|
dc.contributor.author |
Samreen Saleem |
|
dc.contributor.author |
Tabinda Fatima |
|
dc.contributor.author |
Siddiqi, Humaira Masood |
|
dc.contributor.author |
Bushra Mirza |
|
dc.date.accessioned |
2023-01-19T09:23:38Z |
|
dc.date.available |
2023-01-19T09:23:38Z |
|
dc.date.issued |
2013-01-20 |
|
dc.identifier.citation |
Noureen, A., Saleem, S., Fatima, T., Siddiqi, H. M., & Mirza, B. (2013). Synthesis, characterization, biological evaluation and QSAR of some Schiff base esters: promising new antitumor, antioxidant and anti-inflammatory agents. Pak. J. Pharm. Sci, 26(1), 113-124. |
en_US |
dc.identifier.issn |
1011-601X |
|
dc.identifier.uri |
http://142.54.178.187:9060/xmlui/handle/123456789/16107 |
|
dc.description.abstract |
We report the synthesis, characterization, biological evaluation and quantitative structure-activity relationship of some Schiff base esters as promising new antitumor, antioxidant and anti-inflammatory agents. The Schiff base esters were synthesized by two synthetic routes using variably substituted hydroxy benzaldehydes with para amino phenol in appreciable yields. All the newly synthesized esters have been characterized by 1H-NMR,.13C-NMR, FT-IR techniques and elemental analysis. The synthesized esters were examined for antioxidant, antitumor and anti-inflammatory potentials through different bioassays and quantitative structure-activity relationship was studied. Bioassays showed encouraging results and indicated that some of these title compounds may have potential for further pharmacological investigations. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Karachi: Pakistan Botanical Society, University of Karachi |
en_US |
dc.subject |
Schiff base esters |
en_US |
dc.subject |
potato disc antitumor assay |
en_US |
dc.subject |
free radical induced oxidative DNA damage analysis |
en_US |
dc.subject |
Carrageenan induced rat hind paw edema test. |
en_US |
dc.title |
Synthesis, characterization, biological evaluation and QSAR of some Schiff base esters: Promising new antitumor, antioxidant and antiinflammatory agents |
en_US |
dc.type |
Article |
en_US |