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Synthesis, characterization, biological evaluation and QSAR of some Schiff base esters: Promising new antitumor, antioxidant and antiinflammatory agents

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dc.contributor.author Asma Noureen
dc.contributor.author Samreen Saleem
dc.contributor.author Tabinda Fatima
dc.contributor.author Siddiqi, Humaira Masood
dc.contributor.author Bushra Mirza
dc.date.accessioned 2023-01-19T09:23:38Z
dc.date.available 2023-01-19T09:23:38Z
dc.date.issued 2013-01-20
dc.identifier.citation Noureen, A., Saleem, S., Fatima, T., Siddiqi, H. M., & Mirza, B. (2013). Synthesis, characterization, biological evaluation and QSAR of some Schiff base esters: promising new antitumor, antioxidant and anti-inflammatory agents. Pak. J. Pharm. Sci, 26(1), 113-124. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16107
dc.description.abstract We report the synthesis, characterization, biological evaluation and quantitative structure-activity relationship of some Schiff base esters as promising new antitumor, antioxidant and anti-inflammatory agents. The Schiff base esters were synthesized by two synthetic routes using variably substituted hydroxy benzaldehydes with para amino phenol in appreciable yields. All the newly synthesized esters have been characterized by 1H-NMR,.13C-NMR, FT-IR techniques and elemental analysis. The synthesized esters were examined for antioxidant, antitumor and anti-inflammatory potentials through different bioassays and quantitative structure-activity relationship was studied. Bioassays showed encouraging results and indicated that some of these title compounds may have potential for further pharmacological investigations. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Botanical Society, University of Karachi en_US
dc.subject Schiff base esters en_US
dc.subject potato disc antitumor assay en_US
dc.subject free radical induced oxidative DNA damage analysis en_US
dc.subject Carrageenan induced rat hind paw edema test. en_US
dc.title Synthesis, characterization, biological evaluation and QSAR of some Schiff base esters: Promising new antitumor, antioxidant and antiinflammatory agents en_US
dc.type Article en_US


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