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Effect of selected anti-malarial drugs on the blood chemistry and brain serotonin levels in male rabbits

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dc.contributor.author Eigbibhalu, Ukpo Grace
dc.contributor.author Albert Taiwo, Ebuehi Osaretin
dc.contributor.author Douglass, Idiakheua Akhabue
dc.contributor.author Abimbola, Efunogbon Aderonke
dc.date.accessioned 2023-01-19T09:26:45Z
dc.date.available 2023-01-19T09:26:45Z
dc.date.issued 2013-01-20
dc.identifier.citation Eigbibhalu, U. G., Taiwo, E. O. A., Douglass, I. A., & Abimbola, E. A. (2013). Effect of selected anti-malarial drugs on the blood chemistry and brain serotonin levels in male rabbits. Pakistan Journal of Pharmaceutical Sciences, 26(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16108
dc.description.abstract The effects of oral administration of sulfadoxine - pyrimethamine (SP), artesunate (A) and sulfadoxine - pyrimethamine - artesunate (SPA) on blood chemistry and brain serotonin in rabbits were investigated. Forty rabbits were divided into four groups of ten animals each. The group that served as the control received 2ml of distilled water while the other groups were received 1.25/25mg base/kg body weight of SP, 3.3mg/kg body weight of A and 1.25/25mg base/kg body weight of SP plus 3.3mg/kg body weight of A respectively by oral route daily for 3 days in a week for four weeks. At the end of each week of drug administration, three rabbits from each group were anaesthetized, blood was taken from the jugular veins using sterile needle and serum was extracted. The rabbits were sacrificed by decapitation; the liver and brain tissues were excised and homogenized. Total blood protein, cholesterol, triglyceride, albumin, creatinine and urea concentrations, creatine kinase, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase, ALP activities were assayed using CX5 synchron autoanalyzer. The brain and liver serotonin levels were determined using high performance liquid chromatography (HPLC). There were no significant differences (P ≤ 0.05) in the concentrations of serum albumin, urea, creatinine, cholesterol and triglyceride of rabbits administered SP, A and SPA for 4 weeks, except in serum total protein. No significant differences existed in the activities of AST, ALT and ALP, except in creatine kinase which was elevated in the control. The brain serotonin levels of rabbits administered SP, A and SPA were significantly higher as compared to the control throughout the duration of the study Data of the study indicate that oral administration of SP, A or SPA in rabbits do not affect blood chemistry, but affected brain serotonin levels and could alter some neural functions. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Botanical Society, University of Karachi en_US
dc.subject Artesunate, sulphadoxine - pyrimethamine en_US
dc.subject aspartate transaminase (AST) en_US
dc.subject alanine transaminase (ALT), en_US
dc.subject alkaline phosphatase en_US
dc.subject ALP, serotonin en_US
dc.title Effect of selected anti-malarial drugs on the blood chemistry and brain serotonin levels in male rabbits en_US
dc.type Article en_US


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