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Cytoprotective activity of mulberry leaf extract against oxidative stress-induced cellular injury in rats

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dc.contributor.author Jaruchotikamol, Atika
dc.contributor.author Pannangpetch, Patchareewan
dc.date.accessioned 2023-01-19T09:39:50Z
dc.date.available 2023-01-19T09:39:50Z
dc.date.issued 2013-01-20
dc.identifier.citation Jaruchotikamol, A., & Pannangpetch, P. (2013). Cytoprotective activity of mulberry leaf extract against oxidative stress-induced cellular injury in rats. Pakistan journal of pharmaceutical sciences, 26(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16115
dc.description.abstract Morus alba Linn. (MA), mulberry leaves have been used as a beverage for prevention of various diseases including hyperlipidemia and hyperglycemia. Recently, the antioxidant activities of the MA leaf extract have been reported. The objective of this study was to investigate the effect of the MA leaf extract on free radical-induced cellular injury. In the in vitro models, the extract scavenged stable free radical (1, 1-diphenyl-2-picrylhydrazyl; DPPH) in a concentration-dependent manner with an IC50 of 20.10±0.78 µg/ml. The extract protected the erythrocytes from free radical (2, 2’-azobis (2-amidinopropane) dihydrochloride; AAPH)-induced hemolysis with an IC50 of 74.22±9.87 µg/ml. Additionally, the extract significantly prevented the gastric mucosal injury induced by ischemia-reperfusion (I/R) in rats when given orally at doses of 0.25 and 0.50 g/kg/day for 3 consecutive days (p<0.05; n=7). However, this effect was not found when the higher doses (1 and 2 g/kg/day) of the extract were tested. In conclusion, these results indicate that the MA leaf extract possesses the cytoprotective activity against free radical-induced cell injury. Therefore, when given at the appropriate dose range, the mulberry leaf may potentially be used as a food supplement in patients with certain diseases in which the oxidative stress-induced cellular injury is pathologically involved. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Botanical Society, University of Karachi en_US
dc.subject Morus alba Linn en_US
dc.subject mulberry en_US
dc.subject cytoprotective activity en_US
dc.subject anti-oxidant activity en_US
dc.subject ischemia-reperfusion. en_US
dc.title Cytoprotective activity of mulberry leaf extract against oxidative stress-induced cellular injury in rats en_US
dc.type Article en_US


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