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Solubility of amphotericin B in water-lecithin-dispersions and lecithin-based submicron emulsions

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dc.contributor.author Salerno, Claudia
dc.contributor.author Perez, Sebastian
dc.contributor.author Monteagudo, Ezequiel
dc.contributor.author Carlucci, Adriana
dc.contributor.author Bregni, Carlos
dc.date.accessioned 2023-01-19T10:10:51Z
dc.date.available 2023-01-19T10:10:51Z
dc.date.issued 2013-01-20
dc.identifier.citation Claudia, S., Sebastian, P., Ezequiel, M., Adriana, C., & Carlos, B. (2013). Solubility of amphotericin B in water-lecithin-dispersions and lecithin-based submicron emulsions. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16119
dc.description.abstract The aim of this work was to evaluate water-lecithin-dispersions (WLDs) as carriers for Amphotericin B (AmB) and to compare the drug solubility in WLDs and O/W lecithin-based submicron emulsions (SMEs) in order to evaluate the influence of lecithin content on the dosage form solubilization of the active compound. WLDs and different SMEs with either 1.2 or 2.4% of lecithin were prepared. WLD with 2.4% lecithin show a 10-fold increase in solubilization of AmB compared with 1.2% lecithin WLD. SMEs with 1.2% lecithin show an increase of over 400 times in solubilization compared with WLD containing the same concentration of lecithin, whereas SMEs with 2.4% lecithin show an increase of over 40 times compared with the corresponding WLD. Drug solubilization in SMEs with 2.4% lecithin is not significantly greater than in those containing 1.2% lecithin. The content of surfactant Brij 97® had a significant influence on drug solubilization in SMEs (P<0.05). Results indicate that indicate that SMEs are proper systems to solubilize AmB. It can be assumed that solubilization is due to the formulation microstructure and not to the separate components themselves en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Botanical Society, University of Karachi en_US
dc.subject lecithin en_US
dc.subject dispersions en_US
dc.subject submicron emulsion en_US
dc.subject Amphotericin B en_US
dc.title Solubility of amphotericin B in water-lecithin-dispersions and lecithin-based submicron emulsions en_US
dc.type Article en_US


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