PASTIC Dspace Repository

Modulation of drug release by utilizing pH-independent matrix system comprising water soluble drug verapamil hydrochloride

Show simple item record

dc.contributor.author Dheeraj Baviskar
dc.contributor.author Rajesh Sharma
dc.contributor.author Dinesh Jain
dc.date.accessioned 2023-01-20T04:33:20Z
dc.date.available 2023-01-20T04:33:20Z
dc.date.issued 2013-01-20
dc.identifier.citation Baviskar, D., Sharma, R., & Jain, D. (2013). Modulation of drug release by utilizing pH-independent matrix system comprising water soluble drug verapamil hydrochloride. Pakistan Journal of Pharmaceutical Sciences, 26(1). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16126
dc.description.abstract The present study was undertaken to investigate the effect of hydrophilic, plastic and hydrophobic types of polymers and their content level on the release profile of drug from matrix systems. To improve therapeutic efficacy, systemic absorption and patient compliance a sustained release matrix tablets of Verapamil HCl (VHE) has been developed. VHE tablets were prepared by using various polymers like hydrophilic (HPMC K15M CR), plastic (Kollidon SR), hydrophobic (Eudragit RSPO) and combination of best two resulted polymers using direct compression. A 32 full factorial design was applied to study the effect of polymers on drug release. For the combination of polymers, selected factors HPMC K15 CR (X1) and Eudragit RSPO (X2) showed positive influence on drug release at 18 hrs and 20 hrs. The release profile of VHE formulation exhibits Higuchi model with anomalous diffusion release. Accelerated stability trials for 3 months proved reproducibility. A good correlation between the dissolution profiles and bioavailability indicated a linear relationship between in vitro – in vivo data. The current study attained the successful design, development and optimization of controlled release once-a-day formulation of VHE. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Botanical Society, University of Karachi en_US
dc.subject Verapamil HCl en_US
dc.subject Matrix tablets en_US
dc.subject HPMC K 15M en_US
dc.subject Eudragit RSPO en_US
dc.subject optimization en_US
dc.subject in vitro drug releas en_US
dc.subject in vivo evaluation. en_US
dc.title Modulation of drug release by utilizing pH-independent matrix system comprising water soluble drug verapamil hydrochloride en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account