Abstract:
Prostate cancer is a serious multidimensional disorder that arises because of misrepresentation of
signaling cascades and acquired resistance against apoptosis. It is progressively becoming more
insurmountable because of rheostat like switching of oncogenic signaling in androgen dependent and
androgen depleted microenvironment. Additionally, oncogenic fusion proteins have been explored in prostate
cancer tissues thus adding another layer of complexity to the targeting of protein network in cancer cell and
generate hurdles in the standardization of therapy. In this review we briefly describe identified oncogenic
fusion transcripts in prostate cancer and suggest utilization of this biomarker for prostate cancer diagnosis
alongwith standard PSA and immunohistochemistry analysis in Pakistan. We also provide overview of animal
model studies to interpret the efficacy of vitamins.
