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Chronic administration of St. John’s Wort attenuates alcohol intake and brain indoleamine 2, 3-dioxygenase activity in mice

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dc.contributor.author Warda Naseem
dc.contributor.author Samina Bano
dc.date.accessioned 2023-01-20T04:55:24Z
dc.date.available 2023-01-20T04:55:24Z
dc.date.issued 2018-07-20
dc.identifier.citation Naseem, W., & Bano, S. (2018). Chronic administration of St. John’s Wort attenuates alcohol intake and brain indoleamine 2, 3-dioxygenase activity in mice. Pak. J. Pharm. Sci, 31(4), 1203-1207. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16148
dc.description.abstract Present study aims to elucidate the effects of chronic administration of St. John’s Wort (SJW) (500mg/kg) on brain tryptophan (TRP) metabolites and indoleamine 2-3 dioxygenase (IDO) activity in alcohol treated mice. Locally bred Albino BALB/c mice, weighing 20-25g were divided into three groups (untreated controls, Alcohol, Alcohol +Drug) having 6 mice in each. Freshly prepared ethanol solution was administered in drinking water in the proportion of 5% for three days or 8% for 3 weeks to two groups. After 3 weeks drug group was treated with SJW (dissolved in ethanol: saline 1:3 v/v) at a dose of 500mg/kg was administered orally for 1 week. During treatment alcohol intake was monitored .In present finding chronic administration of SJW significantly reduced ethanol intake by 78.6% (P<0.001) in mice. Data analyzed by student‘s t-test indicates that SJW remarkably reduce kynurenine (KYN) by 60.9% (P<0.001) and KYN/TRP ratio (IDO) activity) by 70.9% (P<0.001) in brain. Low serotonin level promotes alcohol intake. Present results suggest that SJW decreases alcohol intake by inhibiting IDO thereby shifting TRP catabolism towards serotonin synthesis. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Botanical Society, University of Karachi en_US
dc.subject Alcohol, SJW en_US
dc.subject tryptophan, kynurenine en_US
dc.subject IDO. en_US
dc.title Chronic administration of St. John’s Wort attenuates alcohol intake and brain indoleamine 2, 3-dioxygenase activity in mice en_US
dc.type Article en_US


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