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Biological screening of Scrophularia nodosa extract and its fractions

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dc.contributor.author Mansoor Ahmad
dc.contributor.author Noor Muhammad
dc.contributor.author Mehjabeen
dc.contributor.author Noor Jahan
dc.contributor.author Noor Jahan
dc.contributor.author Manzoor Ahmad
dc.contributor.author Obaidullah
dc.date.accessioned 2023-01-20T05:00:18Z
dc.date.available 2023-01-20T05:00:18Z
dc.date.issued 2012-04-03
dc.identifier.citation Ahmad, M., Muhammad, N., Jahan, N., Alam, S. M., & Ahmad, M. (2012). Biological screening of Scrophularia nodosa extract and its fractions. Pakistan Journal of Pharmaceutical Sciences, 25(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16157
dc.description.abstract Biological screening of Scrophularia nodosa crude extract and its fractions (hexane, chloroform, ethyl-acetate, n-butanol and aqueous) was carried out on phytotoxicity, cytotoxicity, antibacterial, antifungal and analgesic activities. Crude extract and its fractions produced 50-100% phytotoxicity at 1000µg/ml concentration whereas 25-77% phytotoxicity was observed at 10µg/ml concentration. The fractions exhibited significant antibacterial and antifungal effects. The non-toxic results of this plant were recorded in Brine Shrimps Bioassay method at all concentrations. Similarly no significant insecticidal activity was observed in crude extracts and fractions. Analgesic activity results of S. nodosa in mice were found highly significant in crude extract as compared to fractions. In writhing test crude extract at 500 mg/kg showed 65.6% highest inhibitory response in mice. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject S. nodosa en_US
dc.subject antioxidant en_US
dc.subject analgesic en_US
dc.subject phytotoxic en_US
dc.subject hemagglutination en_US
dc.title Biological screening of Scrophularia nodosa extract and its fractions en_US
dc.type Article en_US


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