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Oral administration of honokiol attenuates airway inflammation in asthmatic mouse model

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dc.contributor.author Teng Hong
dc.contributor.author Hu Min
dc.contributor.author Zeng Hui
dc.contributor.author Liu Yuejian
dc.contributor.author Yuan Lixing
dc.contributor.author Liang, Xie Zheng
dc.date.accessioned 2023-01-20T05:00:35Z
dc.date.available 2023-01-20T05:00:35Z
dc.date.issued 2018-07-20
dc.identifier.citation Hong, T., Min, H., Hui, Z., Yuejian, L., Lixing, Y., & Liang, X. Z. (2018). Oral administration of honokiol attenuates airway inflammation in asthmatic mouse model. Pakistan Journal of Pharmaceutical Sciences, 31(4), 1279-1285. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16158
dc.description.abstract Allergic asthma is a disease that pathologically characterized by eosinophilia infiltration, airway inflammation and hyper responsiveness. In this study, we evaluated the anti-inflammatory and anti-allergy possibilities of honokiol, a bi-phenolic compound obtained from species of the genus Magnolia, which has long been involved in traditional Chinese prescriptions for asthma-related lung diseases, in an ovalbumin-induced mouse model of allergic asthma. We found honokiol significantly inhibited the eosinophilia infiltration, reduced the airway inflammation and suppressed the production of inflammatory cytokines) as well as the IgE in serum. Moreover, MMP-9 and? (IL-4 and IFN- NF-кB were found to be involved in the honokiol induced biological process. These results suggested that honokiol may be a possible candidate in the treatment of lung asthma related diseases. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Botanical Society, University of Karachi en_US
dc.subject Honokiol, asthma en_US
dc.subject anti-allergy en_US
dc.subject anti-inflammation. en_US
dc.title Oral administration of honokiol attenuates airway inflammation in asthmatic mouse model en_US
dc.type Article en_US


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