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Terpenoids from Juniperus procera with hepatoprotective activity

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dc.contributor.author Saleh Ibrahim Alqasoumi
dc.contributor.author Maged Saad Abdel-Kader
dc.date.accessioned 2023-01-20T05:00:46Z
dc.date.available 2023-01-20T05:00:46Z
dc.date.issued 2012-04-04
dc.identifier.citation Alqasoumi, S. I., & Abdel-Kader, M. S. (2012). Terpenoids from Juniperus procera with hepatoprotective activity. Pakistan journal of pharmaceutical sciences, 25(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16159
dc.description.abstract The petroleum ether fraction of Juniperus procera showed significant activity as hepatoprotective when investigated against carbon tetrachloride induced liver injury. The hepatoprotective activity was evaluated through the quantification of biochemical parameters and confirmed using histopathology analysis. Phytochemical investigation of the petroleum ether fraction utilizing different chromatographic techniques resulted in the isolation of six known diterpenoids namely: 4-epi-abietol (1), ferruginol (2), hinokiol (3), sugiol (4), Z-communic acid (5) and hinokiol-1-one 3β,12-dihydroxyabieta-8,11,13-triene-1-one) (6), in addition to the sesquiterpene 8α-acetoxyelemol (7). Both physical and spectral data were used for structure determination and all isolates were evaluated for their hepatoprotective activity. Compounds 1 and 4 were the most effective in reducing the elevated liver enzymes as indication for liver protection. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Juniperus procera en_US
dc.subject diterpenoids en_US
dc.subject sesquiterpene en_US
dc.subject hepatoprotective en_US
dc.title Terpenoids from Juniperus procera with hepatoprotective activity en_US
dc.type Article en_US


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