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Antidiarrhoeal effects of the methanol extract of the aerial parts of Mitracarpus villosus

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dc.contributor.author John-Africa, Lucy Binda
dc.date.accessioned 2023-01-20T05:01:25Z
dc.date.available 2023-01-20T05:01:25Z
dc.date.issued 2018-07-20
dc.identifier.citation John-Africa, L. B. (2018). Antidiarrhoeal effects of the methanol extract of the aerial parts of Mitracarpus villosus. Pakistan Journal of Pharmaceutical Sciences, 31(4). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16161
dc.description.abstract Mitracarpus villosus (S.W) DC is used as treatment for diarrhoea and dysentery in some communities of West Africa. This study aimed to investigate the antidiarrhoeal effects of the methanol extract of the aerial parts of Mitracarpus villosus in mice to substantiate its use as an antidiarrhoeal preparation in traditional medicine. The mean lethal dose (LD50) of the extract was assessed in mice. The effect of the extract (100, 200 and 400 mg/kg body weight) on diarrhoea was evaluated against castor oil- induced diarrhoea. Castor oil-induced enteropooling was used to determine the effect of the plant extract on intestinal intraluminal fluid accumulation and the activity of Mitracarpus villosus extract on intestinal motility was investigated by means of the charcoal meal test and distal colonic bead expulsion time. Effect on gastric emptying was also evaluated. The extract decreased the number of wet feaces produced in a significant (P<0.05), dose-related manner. The extract also caused significant reduction of both the quantity of fluid accumulated in the intestinal lumen and small intestinal propulsion. The decreases were dose-dependent. Distal colonic propulsion time was delayed; however, the values obtained were not significantly different from control. Likewise, gastric emptying was significantly delayed. The results from this study showed that the methanol extract of the aerial parts of Mitracarpus villosus exhibited significant antidiarrhoeal activities. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Botanical Society, University of Karachi en_US
dc.subject Intestinal propulsion en_US
dc.subject fluid accumulation en_US
dc.subject gastric emptying. en_US
dc.title Antidiarrhoeal effects of the methanol extract of the aerial parts of Mitracarpus villosus en_US
dc.type Article en_US


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