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Effect of aceclofenac on pharmacokinetic of phenytoin

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dc.contributor.author Bikash Medhi
dc.contributor.author Joshi, Rupa
dc.contributor.author Prakash, Ajay
dc.contributor.author Bansal, Yogender Singh
dc.contributor.author Attrey, Sunil Dutt
dc.contributor.author Singh, Dalbir
dc.contributor.author Pandhi, Promila
dc.date.accessioned 2023-01-20T05:03:29Z
dc.date.available 2023-01-20T05:03:29Z
dc.date.issued 2012-04-01
dc.identifier.citation Medhi, B., Joshi, R., Prakash, A., Bansal, Y. S., Attrey, S. D., Singh, D., & Pandhi, P. (2012). Effect of aceclofenac on pharmacokinetic of phenytoin. Pakistan Journal of Pharmaceutical Sciences, 25(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16165
dc.description.abstract Aceclofenac is presently most commonly prescribed analgesic for chronic pain and inflammatory conditions. In clinical practice, phenytoin and aceclofenac are used in a chronic condition of generalized seizure with concomitant chronic pain. Hence there are chances of drug-drug interaction because modulations of isoenzymes involved in metabolism of phenytoin and aceclofenac are CYP2C9/10 and CYP2C19. It is important to maintain the therapeutic level of phenytoin in plasma for effective control of seizure. So, the aim of the study was to determine the effect of aceclofenac on the pharmacokinetics of phenytoin in rabbits. In a parallel design study, phenytoin 30 mg/kg/day per oral was given daily for seven days. On day 7, blood samples were taken at various time intervals between 0-24 hours. In aceclofenac group, phenytoin was administered for seven days as above. On day 8, aceclofenac 14 mg/kg alongwith phenytoin 30 mg/kg/day was administered and blood samples drawn as above. Plasma phenytoin levels were assayed by HPLC and pharmacokinetic parameters were calculated. In aceclofenac group, there was decrease in t½el than phenytoin group significant changes were observed in the pharmacokinetic parameters in aceclofenac treated group. These results suggest that aceclofenac alter the pharmacokinetics of phenytoin. Confirmation of these results in human studies will warrant changes in phenytoin dose or frequency when aceclofenac is co-administered with it. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Phenytoin en_US
dc.subject aceclofenac en_US
dc.subject pharmacokinetics en_US
dc.title Effect of aceclofenac on pharmacokinetic of phenytoin en_US
dc.type Article en_US


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