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Comparison of bioavailability and pharmacokinetics of diclofenac sodium and diclofenac potassium in normal and alloxan-diabetic rabbits

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dc.contributor.author Mahmood Ahmad
dc.contributor.author Muhammad Iqbal
dc.contributor.author Ghulam Murtaza
dc.date.accessioned 2023-01-20T05:03:50Z
dc.date.available 2023-01-20T05:03:50Z
dc.date.issued 2012-04-02
dc.identifier.citation Ahmad, M., Iqbal, M., & Murtaza, G. (2012). Comparison of bioavailability and pharmacokinetics of diclofenac sodium and diclofenac potassium in normal and alloxan-diabetic rabbits. Pak. J. Pharm. Sci, 25(2), 301-306. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16166
dc.description.abstract The present study was undertaken to compare the bioavailability and pharmacokinetic parameters of diclofenac sodium and diclofenac potassium in normal and experimentally induced diabetic state in 24 rabbits using a validated reversed phase HPLC method with a washout period of one week. Biochemical and physiological parameters were measured in normal and diabetic rabbits. Primary kinetic parameters i.e. AUC0-∞, Cmax, tmax and other disposition kinetics were determined with non-compartmental procedure. A paired t-test for normal and alloxan treated rabbits revealed a significant decrease in packed cell volume and a significant increase in glucose, total lipids, total proteins, albumin and globulin were observed in diabetic (metabolically altered) rabbits. Plasma concentration of diclofenac (sodium) and diclofenac (potassium) decreased in diabetic condition. Significantly high concentration of diclofenac (potassium) was observed in normal and diabetic conditions as compared to diclofenac (sodium). The variation in bioavailability and disposition of diclofenac sodium and diclofenac potassium in diabetic state will require adjustment of the dosage regimen prescribed for diabetics in clinical setting. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Bioavailability en_US
dc.subject pharmacokinetics en_US
dc.subject diclofenac sodium en_US
dc.subject diclofenac potassium en_US
dc.subject diabetic state en_US
dc.title Comparison of bioavailability and pharmacokinetics of diclofenac sodium and diclofenac potassium in normal and alloxan-diabetic rabbits en_US
dc.type Article en_US


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