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Hypolipidemic effect of aqueous extract of Carum carvi (black Zeera) seeds in diet induced hyperlipidemic rats

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dc.contributor.author Muhammad Rashad Saghir
dc.contributor.author Soban Sadiq
dc.contributor.author Salma Nayak
dc.contributor.author Muhammad Usman Tahir
dc.date.accessioned 2023-01-20T05:04:33Z
dc.date.available 2023-01-20T05:04:33Z
dc.date.issued 2012-04-06
dc.identifier.citation Saghir, M. R., Sadiq, S., Nayak, S., & Tahir, M. U. (2012). Hypolipidemic effect of aqueous extract of Carum carvi (black Zeera) seeds in diet induced hyperlipidemic rats. Pakistan Journal of Pharmaceutical Sciences, 25(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16168
dc.description.abstract Medicinal plants play a key role in preventing various diseases. Hyperlipidemia is a major contributor to the pathogenesis of cardiovascular diseases. The purpose of the present study was to assess the effect of aqueous extract of Carum carvi seeds in diet induced hyperlipidemia in rats. 2% cholesterol diet were given to rats for six weeks and rats showed high lipid levels were included in the study. Then all rats were divided into, normal control group (A), hyperlipidemia positive control group (B), and the remaining two groups (C and D) served as experimental groups. Group C hyperlipidemic experimental rats received aqueous dried extract of Carum carvi seeds at 60 mg/kg of body weight for eight weeks on daily basis. On the other hand group D rats received simvastatin at 1.0 mg/kg body weight for eight weeks. Blood samples were collected after eight weeks. The hyperlipidemic positive control group rats showed variable increase in serum triglycerides, LDL and total cholesterol levels. Serum HDL levels decreased in hyperlipidemic positive control groups. Carum carvi and simvastatin significantly decreased the levels of these parameters in rats. On comparison Carum carvi reduced lipid levels more, effectively than the simvastatin. Carum carvi constituents, especially flavonoids and carvone have strong anti-oxidant activity which might be involved in hypolipidemia. In conclusion, Carum carvi aqueous seeds extract decrease lipid levels in diet induced hyperlipidemic rats. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Carum carvi en_US
dc.subject diabetic nephropathy (DN) en_US
dc.subject oxidative stress en_US
dc.subject total cholesterol en_US
dc.subject serum triglycerides en_US
dc.subject LDL (low density lipoproteins) en_US
dc.subject HDL (high density lipoproteins) en_US
dc.title Hypolipidemic effect of aqueous extract of Carum carvi (black Zeera) seeds in diet induced hyperlipidemic rats en_US
dc.type Article en_US


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