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Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer

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dc.contributor.author Abid Hussain
dc.contributor.author Khan, Gul Majid
dc.contributor.author Syed Umer Jan
dc.contributor.author Shefaat Ullah Shah
dc.contributor.author Kifayatullah Shah
dc.contributor.author Muhammad Akhlaq
dc.contributor.author Nouman Rahim
dc.contributor.author Asif Nawaz
dc.contributor.author Abdul Wahab
dc.date.accessioned 2023-01-20T05:11:10Z
dc.date.available 2023-01-20T05:11:10Z
dc.date.issued 2012-04-12
dc.identifier.citation Hussain, A., Khan, G. M., Jan, S. U., Shah, S. U., Shah, K., Akhlaq, M., ... & Wahab, A. (2012). Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer. Pakistan journal of pharmaceutical sciences, 25(2). en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16176
dc.description.abstract The present study was conducted to formulate and evaluate flurbiprofen transdermal gel. A standard calibration curve was constructed to obtain a regression line equation to be used for finding out the concentration of drug in samples. Olive oil was used as penetration enhancer and was added in different concentrations to some selected formulations to see its enhancement effect on in vitro drug release profiles. The prepared gels were evaluated for several physico-chemical parameters to justify their suitability for topical use. The in vitro drug release studies were carried out by using Franz cell diffusion apparatus across both synthetic membrane and excised albino rabbit skin. In order to investigate the drug release mechanism a kinetic approach was made by employing Korsmeyer kinetic model to the in vitro drug release profiles of flurbiprofen. The flurbiprofen topical gels were successfully prepared and could be beneficial for topical use. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Flurbiprofen en_US
dc.subject olive oil en_US
dc.subject transdermal gel en_US
dc.subject in vitro release kinetics en_US
dc.title Effect of olive oil on transdermal penetration of flurbiprofen from topical gel as enhancer en_US
dc.type Article en_US


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