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Development and evaluation of eudragit based microparticles of dexibuprofen for site specific drug release

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dc.contributor.author Qandeel Khalid
dc.contributor.author Mahmood Ahmad
dc.contributor.author Minhas, Muhammad Usman
dc.contributor.author Haroon Rashid
dc.date.accessioned 2023-01-20T05:18:53Z
dc.date.available 2023-01-20T05:18:53Z
dc.date.issued 2018-07-20
dc.identifier.citation Khalid, Q., Ahmad, M., Minhas, M. U., & Rashid, H. (2018). Development and evaluation of eudragit based microparticles of dexibuprofen for site specific drug release. Pak. J. Pharm. Sci, 31(4), 1385-1392. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16189
dc.description.abstract The main purpose of work was to formulate dexibuprofen loaded eudragit L-100 micro particles to acquire site specific delivery of dexibuprofen. Micro particles were formulated by an emulsion solvent evaporation method. Four formulations F1, F2, F3 and F4 having drug to polymer ratio 1:1, 1:2, 1:3 and 1:4, respectively were prepared and characterized. The rheological properties manifested that micro particles were worthy for further pharmaceutical exploitation. No notable drug polymer interaction was perceived in FT-IR spectroscopy. SEM micrographs showed rough surface of micro particles. The resulting micro particles had high entrapment efficiency greater than 70%. The in vitro dexibuprofen release at pH 1.2 exhibited poor drug release with less than 21% while at pH 6.8, 60% of the dexibuprofen was released up till 8th hour. The dexibuprofen release was modified by altering polymer concentration in the formulation. The subsequent micro particles were found to be best fit with zero-order release model. Micro particles were efficiently formulated with a focus to release the drug majorly in small intestine. With increase of polymer concentration enhanced entrapment efficiency and decelerated dexibuprofen release from the micro particles has been achieved. In vitro dexibuprofen studies verified the gastro-resistant property of micro particles thus qualify site specific release in gastrointestinal tract. en_US
dc.language.iso en en_US
dc.publisher Karachi: Pakistan Botanical Society, University of Karachi en_US
dc.subject Eudragit L-100 en_US
dc.subject dexibuprofen en_US
dc.subject pH modulated micro particles en_US
dc.subject emulsion solvent evaporation en_US
dc.subject entrapment efficiency en_US
dc.subject FT-IR spectroscopy en_US
dc.subject in vitro drug release studies. en_US
dc.title Development and evaluation of eudragit based microparticles of dexibuprofen for site specific drug release en_US
dc.type Article en_US


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