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A facile method for the synthesis of 2-(3-hydroxy-1-adamantyl)-2oxoacetic acid and it’s optimization
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| dc.contributor.author | Wang, Hui-fei | |
| dc.contributor.author | Run Gan | |
| dc.contributor.author | Jing Zhou | |
| dc.contributor.author | Qi Liao | |
| dc.contributor.author | Wang, Tian-bao | |
| dc.contributor.author | Zhong, Cai-ling | |
| dc.contributor.author | Xiang, Yuan-yuan | |
| dc.contributor.author | Lin, Hong-bo | |
| dc.contributor.author | Hu, Xiang-nan | |
| dc.date.accessioned | 2023-01-20T05:19:38Z | |
| dc.date.available | 2023-01-20T05:19:38Z | |
| dc.date.issued | 2018-07-20 | |
| dc.identifier.citation | Wang, H. F., Gan, R., Zhou, J., Liao, Q., Wang, T. B., Zhong, C. L., ... & Hu, X. N. (2018). A facile method for the synthesis of 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid and it's optimization. Pakistan Journal of Pharmaceutical Sciences, 31(4). | en_US |
| dc.identifier.issn | 1011-601X | |
| dc.identifier.uri | http://142.54.178.187:9060/xmlui/handle/123456789/16191 | |
| dc.description.abstract | 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid (IV), a key intermediate of saxagliptin for type 2 diabetes mellitus (T2DM), was prepared from 1-adamantanecarboxylic acid(I) via oxidation by potassium permanganate(KMnO4) to afford 3-hydroxy-1-adamantanecarboxylic acid (II), which was treated with a one-pot method to give 1-acetyl-3-hydroxyadamantane (III) followed by oxidation. Some key steps were optimized and the overall yield was about 51% | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Karachi: Pakistan Botanical Society, University of Karachi | en_US |
| dc.subject | Diabetes | en_US |
| dc.subject | key intermediate | en_US |
| dc.subject | saxagliptin | en_US |
| dc.subject | optimization | en_US |
| dc.subject | one-pot method. | en_US |
| dc.title | A facile method for the synthesis of 2-(3-hydroxy-1-adamantyl)-2oxoacetic acid and it’s optimization | en_US |
| dc.type | Article | en_US |
