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Research on effect of minor bupleurum decoction of proliferation and apoptosis of esophageal cancer cell strain eca-109 cell

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dc.contributor.author Li, Xiaofang
dc.contributor.author Sun, Miaomiao
dc.contributor.author Zhao, Zhihua
dc.contributor.author Yang, Jianping
dc.contributor.author Chen, Kuisheng
dc.date.accessioned 2023-01-20T05:54:00Z
dc.date.available 2023-01-20T05:54:00Z
dc.date.issued 2014-09-14
dc.identifier.citation Li, X., Sun, M., Zhao, Z., Yang, J., & Chen, K. (2014). Research on effect of minor bupleurum decoction of proliferation and apoptosis of esophageal cancer cell strain eca-109 cell. Pak J Pharm Sci, 27, 1675-1679. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16221
dc.description.abstract The research protocol is MTT (Methyl Thiazolyl Tetrazolium) method, Hoechst33342 staining method and flow cytometry detection to observe the effect of minor bupleurum decoction on proliferation inhibition and apoptosisinducing of esophageal cancer cell strain Eca-109 cell and its purpose is to discuss the effect. The result of MTT method shows that minor buplerum decoction can obviously inhibit proliferation of esophageal cancer cell strain Eca-109 cell. Apoptosis number of esophageal cancer cell increased with the increase of concentration of tetrandrine by the Hoechst 35528 staining experiment of cancer cell in three different concentrations. Flow cytometry detection result showed that cells in cell cycle G0/G1 of esophageal cancer cell strain Eca-109 cell increased obviously and cell in s period decreased significantly. This research proved that minor bupleurum decoction had anti-tumor effect and can influent proliferation and apoptosis of esophageal cancer cell strain Eca-109 cell. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Minor bupleurum decoction en_US
dc.subject Esophageal cancer en_US
dc.subject Proliferation and apoptosis en_US
dc.title Research on effect of minor bupleurum decoction of proliferation and apoptosis of esophageal cancer cell strain eca-109 cell en_US
dc.type Article en_US


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