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Synthesis of novel derivatives of 4-Pyridine carboxylic acid hydrazide and their activity on central nervous system

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dc.contributor.author Sabahat Naeem
dc.contributor.author Shamim Akhtar
dc.contributor.author Nousheen Mushtaq
dc.contributor.author Arfa Kamil
dc.contributor.author Shaista Zafar
dc.contributor.author Sana Anwar
dc.contributor.author Muhammad Arif
dc.date.accessioned 2023-01-20T06:07:34Z
dc.date.available 2023-01-20T06:07:34Z
dc.date.issued 2014-09-02
dc.identifier.citation Naeem, S., Akhtar, S., Mushtaq, N., Kamil, A., Zafar, S., Anwar, S., & Arif, M. (2014). Synthesis of novel derivatives of 4-Pyridine carboxylic acid hydrazide and their activity on central nervous system. Pakistan Journal of Pharmaceutical Sciences, 27(5), 1401-1409. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16252
dc.description.abstract : Six novel derivatives (2-7) of 4-Pyridine carboxylic acid hydrazide (PCH) were synthesized by treating this lead molecule with substituted arylsulphonyl and benzoyl chlorides. The molecular structures of the newly derived products were characterized by the help of UV Visible, IR, FAB, 1 HNMR spectroscopy and CHN analysis. During the preliminary pharmacological screening, it was observed that the synthesized compounds induced noticeable changes on motor activity of the animals. Interesting structure activity relationship was also observed among the synthesized molecules. Because of the interesting affect on motor activity, the newly synthesized derivatives can further be evaluated for their effects on CNS en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject : 4-Pyridine carboxylic acid hydrazide en_US
dc.subject Sulphonyl and benzoyl chloride en_US
dc.subject Pharmacological screening en_US
dc.title Synthesis of novel derivatives of 4-Pyridine carboxylic acid hydrazide and their activity on central nervous system en_US
dc.type Article en_US


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