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Antidepressant effect and categorization of Inhibitory activity of monoamine oxidase type A and B of ethanolic extract of seeds of Trigonella foenum graecum Linn

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dc.contributor.author Raheela Khursheed
dc.contributor.author Ghazala H Rizwani
dc.contributor.author Viqar Sultana
dc.contributor.author Maryam Ahmed
dc.contributor.author Arfa Kamil
dc.date.accessioned 2023-01-20T06:08:40Z
dc.date.available 2023-01-20T06:08:40Z
dc.date.issued 2014-09-04
dc.identifier.citation Khursheed, R., Rizwani, G. H., Sultana, V., Ahmed, M., & Kamil, A. (2014). Antidepressant effect and categorization of inhibitory activity of monoamine oxidase type A and B of ethanolic extract of seeds of Trigonella foenum graecum Linn. Pakistan journal of pharmaceutical sciences, 27. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16255
dc.description.abstract Trigonella foenum- graecum Linn (Fabaceae) is an annual aromatic herb and no wit is cultivated globally like in Pakistan, Egypt, India, Middle East etc. Traditionally it was used in anorexia, as febrifuge, to soothe gastritis and gastric ulcers, as a galactagogue and as condiment, hypoglycemic agent and employed in various as nervous disorders. The study aimed to investigate the antidepressant effect of ethanolic extract of seeds of Trigonella foenum graecum and underlying mechanism of action. For assessment of antidepressant activity Forced Swimming Test (FST), Tail Suspension Test (TST), Monoamine (MAO) Assay and Locomotor Activity Test were studied. Acute toxicity, Rota Rod and Grip Strength Tests were also performed. The significant declining in immobility time as compared to control was shown in Forced swimming test as compared to tail suspension test. Considerable change was not found in open field test (OFT). EtOH extract of seeds of fenugreek represent maximum significant reduction which was 30 and 24.65%in MAO- A and B activity respectively in the rat’s whole brain as compared to control animals in Monoamine oxidase (MAO) assay. All tested doses were found ineffective in impairment of muscle coordination in Rota rod and in grip strength related to muscle relaxant property. According to experimental findings it is revealed that ethanolic extract of seeds of Trigonella foenum graecum showed antidepressant effect by inhibiting the activity of MAO-A and B. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy, University of Karachi en_US
dc.subject Trigonella foenum graecum Linn en_US
dc.subject antidepressant en_US
dc.subject monoamine oxidase assay en_US
dc.subject neurodegenerative diseases en_US
dc.title Antidepressant effect and categorization of Inhibitory activity of monoamine oxidase type A and B of ethanolic extract of seeds of Trigonella foenum graecum Linn en_US
dc.type Article en_US


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