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Efficacy comparison of rosuvastatin and atorvastatin in the treatment of atherosclerosis and drug safety analysis

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dc.contributor.author Liping, Zeng
dc.contributor.author Xiufang, Liu
dc.contributor.author Tao, Yang
dc.contributor.author Baomin, Zhao
dc.contributor.author Houshuai, Tuo
dc.date.accessioned 2023-01-20T06:10:20Z
dc.date.available 2023-01-20T06:10:20Z
dc.date.issued 2018-09-04
dc.identifier.citation Liping, Z., Xiufang, L., Tao, Y., Baomin, Z., & Houshuai, T. (2018). Efficacy comparison of rosuvastatin and atorvastatin in the treatment of atherosclerosis and drug safety analysis. Pakistan Journal of Pharmaceutical Sciences. en_US
dc.identifier.issn 1011-601X
dc.identifier.uri http://142.54.178.187:9060/xmlui/handle/123456789/16259
dc.description.abstract Previous studies have shown that the commonly used statin lipid lowering drugs can delay the progression of atherosclerotic plaque. Atorvastatin can stabilize atherosclerotic plaque, but it can not reverse atheromatous plaque. This study will compare the efficacy of rosuvastatin and atorvastatin in the treatment of atherosclerosis and try to prove that the use of statins can improve peripheral atherosclerosis and reverse atherosclerotic plaque. The results showed that 10 mg rosuvastatin was more effective than 20 mg atorvastatin in lowering serum lipid level and elevating ABI index, ABI as rosuvastatin group(0.782±0.236) and atorvastatin group(0.541±0.196). After 6 months of treatment, the carotid artery IMT in rosuvastatin group and atorvastatin group decreased compared with before treatment, and the difference was statistically significant (P<0.05). The TC/mmol⋅L-1 is 2.83±0.56 in rosuvastatin group and 3.24±0.71 in atorvastatin group. In addition, rosuvastatin did not increase the risk of adverse reactions compared with atorvastatin. The results confirm that statin therapy can improve peripheral atherosclerosis and reverse atherosclerotic plaques. en_US
dc.language.iso en en_US
dc.publisher Karachi: Faculty of Pharmacy & Pharmaceutical Sciences University of Karachi en_US
dc.subject Rosuvastatin en_US
dc.subject lipid-lowering drug en_US
dc.subject safety index en_US
dc.subject reverse plaque en_US
dc.subject adverse drug reaction en_US
dc.title Efficacy comparison of rosuvastatin and atorvastatin in the treatment of atherosclerosis and drug safety analysis en_US
dc.type Article en_US


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