EFFECT OF GENDER ON EFFICACY OF STREPTOKINASE IN ACUTE ST SEGMENT ELEVATION MYOCARDIAL INFARCTION

Abstract

Objective: To study the relation of gender with the efficacy of thrombolytictherapy. Methodology: It is a cross sectional study conducted from December 2017 toJuly 2018 at Jinnah Hospital Lahore. Patients from single center fulfilling theeligibility criteria for thrombolytic therapy and receiving the therapy were includedand were followed during their hospital stay and their hospital outcome wasrecorded SPSS version 22 was used for analysis. Results: Among 780 patients 52.6% (n = 410) were males. The resolution ofchest pain within 90 mins occurred more in males (69.5%) as compared tofemales (49.7%)(p =.000), wash-out phenomenon was more in males (72.9%)as compared to females (51.6%) (p = .000), ST resolution (22.4% in males21.6% in females) (p=.783) and reperfusion arrhythmias (18.3% in males vs16.2% in females) (p 0.444). Cardiac failure [15.9% in females vs 9.3% males (p=0.005)], reduction in LV ejection fraction (LVEF) [(10.8% in females vs 5.6% inmales (p = 0.008)], sudden cardiac death during hospital stay [females (8.6%)vs males (4.4%) (p=0.015)], immediate hypotension [females 27.3% vs 24.9%(p=0.442)], malignant arrhythmias requiring intervention [females (10%) thanin males (6.6%) (p=0.83)] were more in females as compared to males. Conclusion: Female gender is more prone to complications with less beneficialclinical response to thrombolytic therapy as compared to their counterpartgender.